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Dynamics of in vivo ASC speck formation

Activated danger or pathogen sensors trigger assembly of the inflammasome adaptor ASC into specks, large signaling platforms considered hallmarks of inflammasome activation. Because a lack of in vivo tools has prevented the study of endogenous ASC dynamics, we generated a live ASC reporter through C...

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Bibliographic Details
Main Authors: Kuri Rodríguez, Paola Sofía (Author) , Thumberger, Thomas (Author) , Wittbrodt, Joachim (Author)
Format: Article (Journal)
Language:English
Published: 12 July 2017
In: The journal of cell biology
Year: 2017, Volume: 216, Issue: 9, Pages: 2891-2909
ISSN:1540-8140
DOI:10.1083/jcb.201703103
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1083/jcb.201703103
Verlag, kostenfrei, Volltext: http://jcb.rupress.org/content/early/2017/07/11/jcb.201703103
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Author Notes:Paola Kuri, Nicole L. Schieber, Thomas Thumberger, Joachim Wittbrodt, Yannick Schwab, and Maria Leptin

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