Subclinical disease burden as assessed by whole-body MRI in subjects with prediabetes, subjects with diabetes, and normal control subjects from the general population: the KORA-MRI study
Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of metabolic and cardio-cerebrovascular complications affecting multiple organs in individuals with prediabetes. Subjects without a...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
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| In: |
Diabetes
Year: 2016, Jahrgang: 66, Heft: 1, Pages: 158-169 |
| ISSN: | 1939-327X |
| DOI: | 10.2337/db16-0630 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.2337/db16-0630 Verlag, Volltext: http://diabetes.diabetesjournals.org/content/66/1/158 
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| Verfasserangaben: | Fabian Bamberg, Holger Hetterich, Susanne Rospleszcz, Roberto Lorbeer, Sigrid D. Auweter, Christopher L. Schlett, Anina Schafnitzel, Christian Bayerl, Andreas Schindler, Tobias Saam, Katharina Müller-Peltzer, Wieland Sommer, Tanja Zitzelsberger, Jürgen Machann, Michael Ingrisch, Sonja Selder, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Christian Weber, Birgit Ertl-Wagner, Steffen Massberg, Maximilian F. Reiser, and Annette Peters |
| Zusammenfassung: | Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of metabolic and cardio-cerebrovascular complications affecting multiple organs in individuals with prediabetes. Subjects without a history of stroke, coronary artery disease, or peripheral artery disease were enrolled in a case-control study nested within the Cooperative Health Research in the Region of Augsburg (KORA) FF4 cohort and underwent comprehensive MRI assessment to characterize cerebral parameters (white matter lesions, microbleeds), cardiovascular parameters (carotid plaque, left ventricular function, and myocardial late gadolinium enhancement [LGE]), and metabolic parameters (hepatic proton-density fat fraction [PDFF] and subcutaneous and visceral abdominal fat). Among 400 subjects who underwent MRI, 103 subjects had prediabetes and 54 had established diabetes. Subjects with prediabetes had an increased risk for carotid plaque and adverse functional cardiac parameters, including reduced early diastolic filling rates as well as a higher prevalence of LGE compared with healthy control subjects. In addition, people with prediabetes had significantly elevated levels of PDFF and total and visceral fat. Thus, subjects with prediabetes show early signs of subclinical disease that include vascular, cardiac, and metabolic changes, as measured by whole-body MRI after adjusting for cardiometabolic risk factors. |
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| Beschreibung: | Published online ahead of print October 10, 2016 Gesehen am 13.09.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1939-327X |
| DOI: | 10.2337/db16-0630 |