Botulinum neurotoxin a injections influence stretching of the gastrocnemius muscle-tendon unit in an animal model
Botulinum Neurotoxin A (BoNT-A) injections have been used for the treatment of muscle contractures and spasticity. This study assessed the influence of (BoNT-A) injections on passive biomechanical properties of the muscle-tendon unit. Mouse gastrocnemius muscle (GC) was injected with BoNT-A (n = 18)...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 August 2012
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| In: |
Toxins
Year: 2012, Volume: 4, Issue: 8, Pages: 605-619 |
| ISSN: | 2072-6651 |
| DOI: | 10.3390/toxins4080605 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.3390/toxins4080605 Verlag, kostenfrei, Volltext: http://www.mdpi.com/2072-6651/4/8/605 
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| Author Notes: | Patrick Haubruck, Sandeep Mannava, Johannes F. Plate, Michael F. Callahan, Walter F. Wiggins, Gerhard Schmidmaier, Christopher J. Tuohy, Katherine R. Saul, Thomas L. Smith, Patrick Haubruck, Sandeep Mannava, Johannes F. Plate, Michael F. Callahan, Walter F. Wiggins, Gerhard Schmidmaier, Christopher J. Tuohy, Katherine R. Saul and Thomas L. Smith |
| Summary: | Botulinum Neurotoxin A (BoNT-A) injections have been used for the treatment of muscle contractures and spasticity. This study assessed the influence of (BoNT-A) injections on passive biomechanical properties of the muscle-tendon unit. Mouse gastrocnemius muscle (GC) was injected with BoNT-A (n = 18) or normal saline (n = 18) and passive, non-destructive, in vivo load relaxation experimentation was performed to examine how the muscle-tendon unit behaves after chemical denervation with BoNT-A. Injection of BoNT-A impaired passive muscle recovery (15% vs. 35% recovery to pre-stretching baseline, p < 0.05) and decreased GC stiffness (0.531 ± 0.061 N/mm vs. 0.780 ± 0.037 N/mm, p < 0.05) compared to saline controls. The successful use of BoNT-A injections as an adjunct to physical therapy may be in part attributed to the disruption of the stretch reflex; thereby modulating in vivo passive muscle properties. However, it is also possible that BoNT-A injection may alter the structure of skeletal muscle; thus modulating the in vivo passive biomechanical properties of the muscle-tendon unit. |
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| Item Description: | Gesehen am 13.09.2018 |
| Physical Description: | Online Resource |
| ISSN: | 2072-6651 |
| DOI: | 10.3390/toxins4080605 |