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Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex

The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a...

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Bibliographische Detailangaben
Hauptverfasser: Melzer, Sarah (VerfasserIn) , Michael, Magdalena (VerfasserIn) , Caputi, Antonio (VerfasserIn) , Eliava, Marina (VerfasserIn) , Fuchs, Elke C. (VerfasserIn) , Monyer, Hannah (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2012
In: Science
Year: 2012, Jahrgang: 335, Heft: 6075, Pages: 1506-1510
ISSN:1095-9203
DOI:10.1126/science.1217139
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1126/science.1217139
Verlag, Volltext: https://f1000.com/prime/715597805
Volltext
Verfasserangaben:Sarah Melzer, Magdalena Michael, Antonio Caputi, Marina Eliava, Elke C. Fuchs, Miles A. Whittington, Hannah Monyer
Beschreibung
Zusammenfassung:The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.
Beschreibung:Gesehen am 17.09.2018
Beschreibung:Online Resource
ISSN:1095-9203
DOI:10.1126/science.1217139

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