Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence
This study uses human astrocytes and glioma tumorspheres to generate an atlas of mutant-IDH1-induced epigenomic reprogramming. The findings have implications for understanding mutant IDH function and for optimizing approaches to target IDH-mutant tumors.
Gespeichert in:
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2018
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| In: |
Nature genetics
Year: 2018, Jahrgang: 50, Heft: 1, Pages: 62-72 |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/s41588-017-0001-z |
| Online-Zugang: | Verlag, Pay-per-use, Volltext: http://dx.doi.org/10.1038/s41588-017-0001-z Verlag, Pay-per-use, Volltext: https://www.nature.com/articles/s41588-017-0001-z 
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| Verfasserangaben: | Sevin Turcan, Vladimir Makarov, Julian Taranda, Yuxiang Wang, Armida W.M. Fabius, Wei Wu, Yupeng Zheng, Nour El-Amine, Sara Haddock, Gouri Nanjangud, H. Carl LeKaye, Cameron Brennan, Justin Cross, Jason T. Huse, Neil L. Kelleher, Pavel Osten, Craig B. Thompson and Timothy A. Chan |
| Zusammenfassung: | This study uses human astrocytes and glioma tumorspheres to generate an atlas of mutant-IDH1-induced epigenomic reprogramming. The findings have implications for understanding mutant IDH function and for optimizing approaches to target IDH-mutant tumors. |
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| Beschreibung: | Gesehen am 17.09.2018 Article was first published on 27 November 2017 |
| Beschreibung: | Online Resource |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/s41588-017-0001-z |