ERAP1 overexpression in HPV-induced malignancies: a possible novel immune evasion mechanism
Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) components. These changes can directly influence epitope...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 Jun 2017
|
| In: |
OncoImmunology
Year: 2017, Jahrgang: 6, Heft: 7 |
| ISSN: | 2162-402X |
| DOI: | 10.1080/2162402X.2017.1336594 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1080/2162402X.2017.1336594 Verlag, kostenfrei, Volltext: https://doi.org/10.1080/2162402X.2017.1336594 
|
| Verfasserangaben: | Alina Steinbach, Jan Winter, Miriam Reuschenbach, Renata Blatnik, Alexandra Klevenz, Miriam Bertrand, Stephanie Hoppe, Magnus von Knebel Doeberitz, Agnieszka K. Grabowska, and Angelika B. Riemer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1581025947 | ||
| 003 | DE-627 | ||
| 005 | 20220815012105.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180917s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/2162402X.2017.1336594 |2 doi | |
| 035 | |a (DE-627)1581025947 | ||
| 035 | |a (DE-576)511025947 | ||
| 035 | |a (DE-599)BSZ511025947 | ||
| 035 | |a (OCoLC)1341018754 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Steinbach, Alina |e VerfasserIn |0 (DE-588)1153081563 |0 (DE-627)1014478251 |0 (DE-576)500059543 |4 aut | |
| 245 | 1 | 0 | |a ERAP1 overexpression in HPV-induced malignancies |b a possible novel immune evasion mechanism |c Alina Steinbach, Jan Winter, Miriam Reuschenbach, Renata Blatnik, Alexandra Klevenz, Miriam Bertrand, Stephanie Hoppe, Magnus von Knebel Doeberitz, Agnieszka K. Grabowska, and Angelika B. Riemer |
| 246 | 3 | 0 | |a ERAP 1 |
| 264 | 1 | |c 28 Jun 2017 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.09.2018 | ||
| 520 | |a Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) components. These changes can directly influence epitope presentation and thus T-cell responses against tumor cells. To date, the APM had not been studied systematically in a large array of HPV+ tumor samples. Therefore in this study, systematic expression analysis of the APM was performed on the mRNA and protein level in a comprehensive collection of HPV16+ cell lines. Subsequently, HPV+ cervical tissue samples were examined by immunohistochemistry. ERAP1 (endoplasmic reticulum aminopeptidase 1) was the only APM component consistently altered - namely overexpressed - in HPV16+ tumor cell lines. ERAP1 was also found to be overexpressed in cervical intraepithelial neoplasia and cervical cancer samples; expression levels were increasing with disease stage. On the functional level, the influence of ERAP1 expression levels on HPV16 E7-derived epitope presentation was investigated by mass spectrometry and in cytotoxicity assays with HPV16-specific T-cell lines. ERAP1 overexpression did not cause a complete destruction of any of the HPV epitopes analyzed, however, an influence of ERAP1 overexpression on the presentation levels of certain HPV epitopes could be demonstrated by HPV16-specific CD8+ T-cells. These showed enhanced killing toward HPV16+ CaSki cells whose ERAP1 expression had been attenuated to normal levels. ERAP1 overexpression may thus represent a novel immune evasion mechanism in HPV-induced malignancies, in cases when presentation of clinically relevant epitopes is reduced by overactivity of this peptidase. | ||
| 650 | 4 | |a Antigen processing machinery (APM) | |
| 650 | 4 | |a cervical cancer | |
| 650 | 4 | |a endoplasmic reticulum aminopeptidase 1 (ERAP1) | |
| 650 | 4 | |a human papillomavirus (HPV) | |
| 650 | 4 | |a T-cell epitopes | |
| 700 | 1 | |a Winter, Jan |d 1986- |e VerfasserIn |0 (DE-588)1156489164 |0 (DE-627)1019303050 |0 (DE-576)502212500 |4 aut | |
| 700 | 1 | |a Reuschenbach, Miriam |d 1980- |e VerfasserIn |0 (DE-588)13879734X |0 (DE-627)703109723 |0 (DE-576)309094054 |4 aut | |
| 700 | 1 | |a Blatnik, Renata |e VerfasserIn |0 (DE-588)1142196372 |0 (DE-627)1001305167 |0 (DE-576)494738626 |4 aut | |
| 700 | 1 | |a Hoppe, Stephanie |e VerfasserIn |0 (DE-588)1178032191 |0 (DE-627)1049112687 |0 (DE-576)517651173 |4 aut | |
| 700 | 1 | |a Knebel Doeberitz, Magnus von |e VerfasserIn |0 (DE-588)1022165291 |0 (DE-627)71693289X |0 (DE-576)364934239 |4 aut | |
| 700 | 1 | |a Riemer, Angelika |e VerfasserIn |0 (DE-588)1167191420 |0 (DE-627)1030878013 |0 (DE-576)511025688 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t OncoImmunology |d Abingdon : Taylor & Franics, 2012 |g 6(2017,7) Artikel-Nummer e1336594, 9 Seiten |h Online-Ressource |w (DE-627)683365428 |w (DE-600)2645309-5 |w (DE-576)356728366 |x 2162-402X |7 nnas |a ERAP1 overexpression in HPV-induced malignancies a possible novel immune evasion mechanism |
| 773 | 1 | 8 | |g volume:6 |g year:2017 |g number:7 |g extent:9 |a ERAP1 overexpression in HPV-induced malignancies a possible novel immune evasion mechanism |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/2162402X.2017.1336594 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1080/2162402X.2017.1336594 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180917 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1167191420 |a Riemer, Angelika |m 1167191420:Riemer, Angelika |d 50000 |e 50000PR1167191420 |k 0/50000/ |p 10 |y j | ||
| 998 | |g 1022165291 |a Knebel Doeberitz, Magnus von |m 1022165291:Knebel Doeberitz, Magnus von |d 910000 |d 912000 |e 910000PK1022165291 |e 912000PK1022165291 |k 0/910000/ |k 1/910000/912000/ |p 8 | ||
| 998 | |g 1178032191 |a Hoppe, Stephanie |m 1178032191:Hoppe, Stephanie |d 140000 |e 140000PH1178032191 |k 0/140000/ |p 7 | ||
| 998 | |g 1142196372 |a Blatnik, Renata |m 1142196372:Blatnik, Renata |d 50000 |e 50000PB1142196372 |k 0/50000/ |p 4 | ||
| 998 | |g 13879734X |a Reuschenbach, Miriam |m 13879734X:Reuschenbach, Miriam |d 50000 |e 50000PR13879734X |k 0/50000/ |p 3 | ||
| 998 | |g 1156489164 |a Winter, Jan |m 1156489164:Winter, Jan |d 140000 |e 140000PW1156489164 |k 0/140000/ |p 2 | ||
| 998 | |g 1153081563 |a Steinbach, Alina |m 1153081563:Steinbach, Alina |d 50000 |e 50000PS1153081563 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1581025947 |e 3025688548 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"28 Jun 2017"}],"id":{"eki":["1581025947"],"doi":["10.1080/2162402X.2017.1336594"]},"title":[{"title":"ERAP1 overexpression in HPV-induced malignancies","subtitle":"a possible novel immune evasion mechanism","title_sort":"ERAP1 overexpression in HPV-induced malignancies"}],"person":[{"family":"Steinbach","given":"Alina","roleDisplay":"VerfasserIn","role":"aut","display":"Steinbach, Alina"},{"display":"Winter, Jan","given":"Jan","roleDisplay":"VerfasserIn","role":"aut","family":"Winter"},{"given":"Miriam","role":"aut","roleDisplay":"VerfasserIn","family":"Reuschenbach","display":"Reuschenbach, Miriam"},{"display":"Blatnik, Renata","family":"Blatnik","given":"Renata","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Hoppe","given":"Stephanie","role":"aut","roleDisplay":"VerfasserIn","display":"Hoppe, Stephanie"},{"display":"Knebel Doeberitz, Magnus von","given":"Magnus von","roleDisplay":"VerfasserIn","role":"aut","family":"Knebel Doeberitz"},{"display":"Riemer, Angelika","family":"Riemer","role":"aut","roleDisplay":"VerfasserIn","given":"Angelika"}],"name":{"displayForm":["Alina Steinbach, Jan Winter, Miriam Reuschenbach, Renata Blatnik, Alexandra Klevenz, Miriam Bertrand, Stephanie Hoppe, Magnus von Knebel Doeberitz, Agnieszka K. Grabowska, and Angelika B. Riemer"]},"recId":"1581025947","relHost":[{"part":{"year":"2017","text":"6(2017,7) Artikel-Nummer e1336594, 9 Seiten","extent":"9","issue":"7","volume":"6"},"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"683365428","note":["Gesehen am 13.12.2022"],"disp":"ERAP1 overexpression in HPV-induced malignancies a possible novel immune evasion mechanismOncoImmunology","origin":[{"dateIssuedKey":"2012","publisherPlace":"Abingdon ; Austin, Tex.","publisher":"Taylor & Franics ; Landes Bioscience","dateIssuedDisp":"2012-"}],"titleAlt":[{"title":"Onco Immunology"}],"id":{"eki":["683365428"],"issn":["2162-402X"],"zdb":["2645309-5"]},"pubHistory":["1.2012 -"],"title":[{"title":"OncoImmunology","title_sort":"OncoImmunology"}],"type":{"bibl":"periodical","media":"Online-Ressource"}}],"note":["Gesehen am 17.09.2018"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"physDesc":[{"extent":"9 S."}]} | ||
| SRT | |a STEINBACHAERAP1OVERE2820 | ||