Telomere length in poor-risk chronic lymphocytic leukemia: associations with disease characteristics and outcome
Telomere length in chronic lymphocytic leukemia (CLL) is described as an independent prognostic factor based largely on previously untreated patients from chemotherapy based trials. Here, we studied telomere length associations in high-risk, relapsed/refractory CLL treated with alemtuzumab in the CL...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
|
| In: |
Leukemia and lymphoma
Year: 2017, Volume: 59, Issue: 7, Pages: 1614-1623 |
| ISSN: | 1029-2403 |
| DOI: | 10.1080/10428194.2017.1390236 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1080/10428194.2017.1390236 Verlag, Volltext: https://doi.org/10.1080/10428194.2017.1390236 
|
| Author Notes: | Daniela Steinbrecher, Billy Michael Chelliah Jebaraj, Christof Schneider, Jennifer Edelmann, Florence Cymbalista, Véronique Leblond, Alain Delmer, Stefan Ibach, Eugen Tausch, Annika Scheffold, Johannes Bloehdorn, Michael Hallek, Peter Dreger, Hartmut Döhner, Stephan Stilgenbauer |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1581057091 | ||
| 003 | DE-627 | ||
| 005 | 20220815012742.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180918r20182017xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/10428194.2017.1390236 |2 doi | |
| 035 | |a (DE-627)1581057091 | ||
| 035 | |a (DE-576)511057091 | ||
| 035 | |a (DE-599)BSZ511057091 | ||
| 035 | |a (OCoLC)1341018871 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Steinbrecher, Daniela |e VerfasserIn |0 (DE-588)1166884716 |0 (DE-627)1030760780 |0 (DE-576)510941958 |4 aut | |
| 245 | 1 | 0 | |a Telomere length in poor-risk chronic lymphocytic leukemia |b associations with disease characteristics and outcome |c Daniela Steinbrecher, Billy Michael Chelliah Jebaraj, Christof Schneider, Jennifer Edelmann, Florence Cymbalista, Véronique Leblond, Alain Delmer, Stefan Ibach, Eugen Tausch, Annika Scheffold, Johannes Bloehdorn, Michael Hallek, Peter Dreger, Hartmut Döhner, Stephan Stilgenbauer |
| 264 | 1 | |c 2018 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 24 Oct 2017 | ||
| 500 | |a Gesehen am 18.09.2018 | ||
| 520 | |a Telomere length in chronic lymphocytic leukemia (CLL) is described as an independent prognostic factor based largely on previously untreated patients from chemotherapy based trials. Here, we studied telomere length associations in high-risk, relapsed/refractory CLL treated with alemtuzumab in the CLL2O study (n = 110) of German and French CLL study groups. Telomere length (median 3.28 kb, range 2.52-7.24 kb) was relatively short, since 84.4% of patients had 17p- which is generally associated with short telomeres. Median telomere length was used for dichotomization into short and long telomere subgroups. Telomere length was associated with s-TK (p = .025) and TP53 mutations (p = .050) in untreated patients, while no association with clinical/biological characteristics was observed in relapsed/refractory CLL. Short telomeres had significant association with shorter PFS (p = .018) only in refractory CLL. Presence of short telomeres, loss of genes maintaining genomic integrity (SMC5) and increased incidence of chromothripsis, indicated the prevalence of genomic instability in this high-risk cohort. | ||
| 534 | |c 2017 | ||
| 650 | 4 | |a 17p deletion | |
| 650 | 4 | |a alemtuzumab | |
| 650 | 4 | |a chemo-refractory | |
| 650 | 4 | |a chronic lymphocytic leukemia | |
| 650 | 4 | |a Telomere length | |
| 700 | 1 | |a Dreger, Peter |e VerfasserIn |0 (DE-588)1028891881 |0 (DE-627)732699894 |0 (DE-576)376320966 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Leukemia and lymphoma |d London [u.a.] : Taylor & Francis Group, 1989 |g 59(2018), 7, Seite 1614-1623 |h Online-Ressource |w (DE-627)324746237 |w (DE-600)2030637-4 |w (DE-576)099718170 |x 1029-2403 |7 nnas |a Telomere length in poor-risk chronic lymphocytic leukemia associations with disease characteristics and outcome |
| 773 | 1 | 8 | |g volume:59 |g year:2018 |g number:7 |g pages:1614-1623 |g extent:10 |a Telomere length in poor-risk chronic lymphocytic leukemia associations with disease characteristics and outcome |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/10428194.2017.1390236 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1080/10428194.2017.1390236 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180918 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1028891881 |a Dreger, Peter |m 1028891881:Dreger, Peter |d 910000 |d 910100 |e 910000PD1028891881 |e 910100PD1028891881 |k 0/910000/ |k 1/910000/910100/ |p 13 | ||
| 999 | |a KXP-PPN1581057091 |e 3025765941 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Telomere length in poor-risk chronic lymphocytic leukemia","subtitle":"associations with disease characteristics and outcome","title_sort":"Telomere length in poor-risk chronic lymphocytic leukemia"}],"language":["eng"],"physDesc":[{"extent":"10 S."}],"id":{"doi":["10.1080/10428194.2017.1390236"],"eki":["1581057091"]},"relHost":[{"note":["Gesehen am 08.09.15"],"id":{"zdb":["2030637-4"],"issn":["1029-2403"],"eki":["324746237"]},"physDesc":[{"extent":"Online-Ressource"}],"disp":"Telomere length in poor-risk chronic lymphocytic leukemia associations with disease characteristics and outcomeLeukemia and lymphoma","recId":"324746237","origin":[{"publisher":"Taylor & Francis Group ; Informa Healthcare","dateIssuedDisp":"1989-","dateIssuedKey":"1989","publisherPlace":"London [u.a.] ; London [u.a.]"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.1989/90 -"],"language":["eng"],"part":{"extent":"10","pages":"1614-1623","issue":"7","volume":"59","year":"2018","text":"59(2018), 7, Seite 1614-1623"},"title":[{"title_sort":"Leukemia and lymphoma","title":"Leukemia and lymphoma"}]}],"note":["Published online: 24 Oct 2017","Gesehen am 18.09.2018"],"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"2018"}],"recId":"1581057091","type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"family":"Steinbrecher","display":"Steinbrecher, Daniela","given":"Daniela","role":"aut"},{"given":"Peter","role":"aut","display":"Dreger, Peter","family":"Dreger"}],"name":{"displayForm":["Daniela Steinbrecher, Billy Michael Chelliah Jebaraj, Christof Schneider, Jennifer Edelmann, Florence Cymbalista, Véronique Leblond, Alain Delmer, Stefan Ibach, Eugen Tausch, Annika Scheffold, Johannes Bloehdorn, Michael Hallek, Peter Dreger, Hartmut Döhner, Stephan Stilgenbauer"]}} | ||
| SRT | |a STEINBRECHTELOMERELE2018 | ||