Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial

Context: Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The role of empirical combination therapy comprising at least 2 antibiotics of different mechanisms remains controversial. Objective: To compare the effect of moxifloxacin and meropenem wit...

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Bibliographic Details

Main Authors:	Brunkhorst, Frank Martin (Author) , Büchler, Markus W. (Author)
Format:	Article (Journal)
Language:	English
Published:	May 21, 2012
In:	The journal of the American Medical Association Year: 2012, Volume: 307, Issue: 22, Pages: 2390-2399
ISSN:	1538-3598
DOI:	10.1001/jama.2012.5833
Online Access:	Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1001/jama.2012.5833 Verlag, kostenfrei, Volltext: https://jamanetwork.com/journals/jama/fullarticle/1163895
Author Notes:	Frank M. Brunkhorst, Michael Oppert, Gernot Marx, Frank Bloos, Katrin Ludewig, Christian Putensen, Axel Nierhaus, Ulrich Jaschinski, Andreas Meier-Hellmann, Andreas Weyland, Matthias Gründling, Onnen Moerer, Reimer Riessen, Armin Seibel, Maximilian Ragaller, Markus W. Büchler, Stefan John, Friedhelm Bach, Claudia Spies, Lorenz Reill, Harald Fritz, Michael Kiehntopf, Evelyn Kuhnt, Holger Bogatsch, Christoph Engel, Markus Loeffler, Marin H. Kollef, Konrad Reinhart, Tobias Welte, for the German Study Group Competence Network Sepsis (SepNet)