Biology and significance of circulating and disseminated tumour cells in colorectal cancer
Purpose: More than 130 years ago, circulating tumour cells (CTCs) and disseminated tumour cells (DTCs) have been linked to metastasis. Since then, a myriad of studies attempted to characterise and elucidate the clinical impact of CTCs/DTCs, amongst others in colorectal cancer (CRC). Due to a flood o...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 February 2012
|
| In: |
Langenbeck's archives of surgery
Year: 2012, Jahrgang: 397, Heft: 4, Pages: 535-542 |
| ISSN: | 1435-2451 |
| DOI: | 10.1007/s00423-012-0917-9 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s00423-012-0917-9 Verlag, Volltext: https://doi.org/10.1007/s00423-012-0917-9 
|
| Verfasserangaben: | Gunnar Steinert, Sebastian Schölch, Moritz Koch, Jürgen Weitz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1581189400 | ||
| 003 | DE-627 | ||
| 005 | 20220815014818.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180921s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00423-012-0917-9 |2 doi | |
| 035 | |a (DE-627)1581189400 | ||
| 035 | |a (DE-576)511189400 | ||
| 035 | |a (DE-599)BSZ511189400 | ||
| 035 | |a (OCoLC)1341019003 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Steinert, Gunnar |d 1978- |e VerfasserIn |0 (DE-588)139246657 |0 (DE-627)609450069 |0 (DE-576)31088764X |4 aut | |
| 245 | 1 | 0 | |a Biology and significance of circulating and disseminated tumour cells in colorectal cancer |c Gunnar Steinert, Sebastian Schölch, Moritz Koch, Jürgen Weitz |
| 264 | 1 | |c 15 February 2012 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.09.2018 | ||
| 520 | |a Purpose: More than 130 years ago, circulating tumour cells (CTCs) and disseminated tumour cells (DTCs) have been linked to metastasis. Since then, a myriad of studies attempted to characterise and elucidate the clinical impact of CTCs/DTCs, amongst others in colorectal cancer (CRC). Due to a flood of heterogeneous findings regarding CTCs/DTCs in CRC, this review aims to describe the known facts about CTC/DTC biology and clinical impact. Methods: To identify the basic scientific literature regarding the biology and clinical impact of CTCs/DTCs in CRC, we reviewed the literature in the PubMed database. We focused on publications written in English and published until January 2012. As search terms, we used “colorectal cancer (CRC)”, “colon cancer (CC)”, “CTC”, “DTC”, “bone marrow (BM)”, “lymph node (LN)”, “peripheral blood (PB)”, “significance” and “prognosis”. Results: CTC detection and quantification under standardised conditions is feasible. Several studies in large patient settings have revealed prognostic impact of CTCs in CRC. CRC-derived DTC detection and analysis in BM exhibits a more heterogeneous picture but also shows clinical value. Furthermore, the presence of DTCs in LN has a strong prognostic impact in CRC. Conclusions: Clinical relevance and prognostic significance of CTCs/DTCs in CRC have been clearly demonstrated in many experimental studies. The major challenge in CTC/DTC research is now to harmonise the various identification and detection approaches and consequently to conduct large prospective multi-institutional trials to verify the use of CTCs/DTCs as a valid prognostic and predictive biomarker for clinical routine. | ||
| 650 | 4 | |a Circulating tumour cells | |
| 650 | 4 | |a Clinical significance | |
| 650 | 4 | |a Colorectal cancer | |
| 650 | 4 | |a Disseminated tumour cells | |
| 650 | 4 | |a Epithelial-mesenchymal transition | |
| 650 | 4 | |a Prognostic value | |
| 700 | 1 | |a Schölch, Sebastian |d 1982- |e VerfasserIn |0 (DE-588)143528718 |0 (DE-627)647314029 |0 (DE-576)337540942 |4 aut | |
| 700 | 1 | |a Koch, Moritz |d 1970-2015 |e VerfasserIn |0 (DE-588)124272932 |0 (DE-627)085752592 |0 (DE-576)294096671 |4 aut | |
| 700 | 1 | |a Weitz, Jürgen |e VerfasserIn |0 (DE-588)1022345974 |0 (DE-627)716954451 |0 (DE-576)171632176 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Langenbeck's archives of surgery |d Berlin : Springer, 1998 |g 397(2012), 4, Seite 535-542 |h Online-Ressource |w (DE-627)253770440 |w (DE-600)1459390-7 |w (DE-576)072578564 |x 1435-2451 |7 nnas |a Biology and significance of circulating and disseminated tumour cells in colorectal cancer |
| 773 | 1 | 8 | |g volume:397 |g year:2012 |g number:4 |g pages:535-542 |g extent:8 |a Biology and significance of circulating and disseminated tumour cells in colorectal cancer |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00423-012-0917-9 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00423-012-0917-9 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180921 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1022345974 |a Weitz, Jürgen |m 1022345974:Weitz, Jürgen |d 910000 |d 910200 |e 910000PW1022345974 |e 910200PW1022345974 |k 0/910000/ |k 1/910000/910200/ |p 4 |y j | ||
| 998 | |g 124272932 |a Koch, Moritz |m 124272932:Koch, Moritz |d 910000 |d 910200 |e 910000PK124272932 |e 910200PK124272932 |k 0/910000/ |k 1/910000/910200/ |p 3 | ||
| 998 | |g 143528718 |a Schölch, Sebastian |m 143528718:Schölch, Sebastian |d 910000 |d 910200 |e 910000PS143528718 |e 910200PS143528718 |k 0/910000/ |k 1/910000/910200/ |p 2 | ||
| 998 | |g 139246657 |a Steinert, Gunnar |m 139246657:Steinert, Gunnar |d 910000 |d 910200 |e 910000PS139246657 |e 910200PS139246657 |k 0/910000/ |k 1/910000/910200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1581189400 |e 3026008907 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1581189400"],"doi":["10.1007/s00423-012-0917-9"]},"physDesc":[{"extent":"8 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title":"Biology and significance of circulating and disseminated tumour cells in colorectal cancer","title_sort":"Biology and significance of circulating and disseminated tumour cells in colorectal cancer"}],"origin":[{"dateIssuedDisp":"15 February 2012","dateIssuedKey":"2012"}],"relHost":[{"id":{"zdb":["1459390-7"],"eki":["253770440"],"issn":["1435-2451"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"subtitle":"continues Langenbecks Archiv für Chirurgie : organ of the congresses of the German Society of Surgery : official journal of the German Association of Endocrine Surgeons, affiliated to the German Society of Surgery","title":"Langenbeck's archives of surgery","title_sort":"Langenbeck's archives of surgery"}],"origin":[{"dateIssuedKey":"1998","publisherPlace":"Berlin ; Heidelberg","publisher":"Springer","dateIssuedDisp":"1998-"}],"recId":"253770440","corporate":[{"display":"Deutsche Gesellschaft für Chirurgie","role":"isb"}],"disp":"Biology and significance of circulating and disseminated tumour cells in colorectal cancerLangenbeck's archives of surgery","type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"text":"397(2012), 4, Seite 535-542","extent":"8","pages":"535-542","issue":"4","volume":"397","year":"2012"},"language":["eng"],"pubHistory":["Volume 383, issue 1 (March 1998)-"],"note":["Gesehen am 24.03.25","Teils ungezählte Beil.: Supplement"]}],"language":["eng"],"name":{"displayForm":["Gunnar Steinert, Sebastian Schölch, Moritz Koch, Jürgen Weitz"]},"note":["Gesehen am 21.09.2018"],"person":[{"given":"Gunnar","display":"Steinert, Gunnar","role":"aut","family":"Steinert"},{"display":"Schölch, Sebastian","given":"Sebastian","family":"Schölch","role":"aut"},{"given":"Moritz","display":"Koch, Moritz","role":"aut","family":"Koch"},{"display":"Weitz, Jürgen","given":"Jürgen","role":"aut","family":"Weitz"}],"recId":"1581189400"} | ||
| SRT | |a STEINERTGUBIOLOGYAND1520 | ||