Immune-related ocular toxicities in solid tumor patients treated with immune checkpoint inhibitors: a systematic review
Introduction: Immune-related ocular toxicities are uncommon but serious adverse events that may be associated with the use of immune checkpoint inhibitors. The objective of this review is to assess the incidence and risk of ocular toxicities which are potentially immune-related and occur with immune...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 Feb 2017
|
| In: |
Expert review of anticancer therapy
Year: 2017, Volume: 17, Issue: 4, Pages: 387-394 |
| ISSN: | 1744-8328 |
| DOI: | 10.1080/14737140.2017.1296765 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1080/14737140.2017.1296765 Verlag, Volltext: https://doi.org/10.1080/14737140.2017.1296765 
|
| Author Notes: | Omar Abdel-Rahman, Hani Oweira, Ulf Petrausch, Daniel Helbling, Jan Schmidt, Meinrad Mannhart, Arianeb Mehrabi, Othmar Schöb & Anwar Giryes |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1581226748 | ||
| 003 | DE-627 | ||
| 005 | 20220815015352.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180924s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/14737140.2017.1296765 |2 doi | |
| 035 | |a (DE-627)1581226748 | ||
| 035 | |a (DE-576)511226748 | ||
| 035 | |a (DE-599)BSZ511226748 | ||
| 035 | |a (OCoLC)1341018925 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Abdel-Rahman, Omar M. |e VerfasserIn |0 (DE-588)170878732 |0 (DE-627)06102290X |0 (DE-576)131722972 |4 aut | |
| 245 | 1 | 0 | |a Immune-related ocular toxicities in solid tumor patients treated with immune checkpoint inhibitors |b a systematic review |c Omar Abdel-Rahman, Hani Oweira, Ulf Petrausch, Daniel Helbling, Jan Schmidt, Meinrad Mannhart, Arianeb Mehrabi, Othmar Schöb & Anwar Giryes |
| 264 | 1 | |c 24 Feb 2017 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 24.09.2018 | ||
| 520 | |a Introduction: Immune-related ocular toxicities are uncommon but serious adverse events that may be associated with the use of immune checkpoint inhibitors. The objective of this review is to assess the incidence and risk of ocular toxicities which are potentially immune-related and occur with immune checkpoint treatment of solid tumors.Areas covered: PubMed database has been searched till June 2016. Prospective clinical trials reporting the occurrence of immune-related ocular toxicities in solid tumor patients treated with immune checkpoint inhibitors were included. Eleven trials with 4965 participants were included. These studies included one study for ipilimumab and tremelimumab, three studies for nivolumab, five studies for pembrolizumab and one study comparing pembrolizumab to ipilimumab. No atezolizumab studies were included. The most common ocular toxicities reported with these agents included uveitis and dry eyes. Pooled analysis for odds ratio of all-grade immune-related ocular toxicities is 3.40 [95% CI: 1.32-8.71; P = 0.01].Expert commentary: Despite being uncommon, immune-related ocular toxicities (particularly uveitis and dry eyes) occur with a higher frequency in cancer patients treated immune checkpoint inhibitors compared to those treated with control regimens. | ||
| 650 | 4 | |a nivolumab | |
| 650 | 4 | |a atezolizumab | |
| 650 | 4 | |a ocular toxicities | |
| 650 | 4 | |a Pembrolizumab | |
| 700 | 1 | |a Oweira, Hani |e VerfasserIn |0 (DE-588)1155884973 |0 (DE-627)1018363904 |0 (DE-576)501927395 |4 aut | |
| 700 | 1 | |a Schmidt, Jan |d 1961- |e VerfasserIn |0 (DE-588)1022937995 |0 (DE-627)717335852 |0 (DE-576)366198017 |4 aut | |
| 700 | 1 | |a Mehrabi, Arianeb |d 1967- |e VerfasserIn |0 (DE-588)137664583 |0 (DE-627)594829763 |0 (DE-576)304831263 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Expert review of anticancer therapy |d Abingdon, Oxon : Taylor & Francis, 2001 |g 17(2017), 4, Seite 387-394 |h Online-Ressource |w (DE-627)355690446 |w (DE-600)2090850-7 |w (DE-576)398100047 |x 1744-8328 |7 nnas |a Immune-related ocular toxicities in solid tumor patients treated with immune checkpoint inhibitors a systematic review |
| 773 | 1 | 8 | |g volume:17 |g year:2017 |g number:4 |g pages:387-394 |g extent:8 |a Immune-related ocular toxicities in solid tumor patients treated with immune checkpoint inhibitors a systematic review |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/14737140.2017.1296765 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1080/14737140.2017.1296765 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180924 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 137664583 |a Mehrabi, Arianeb |m 137664583:Mehrabi, Arianeb |d 910000 |d 910200 |e 910000PM137664583 |e 910200PM137664583 |k 0/910000/ |k 1/910000/910200/ |p 7 | ||
| 998 | |g 1022937995 |a Schmidt, Jan |m 1022937995:Schmidt, Jan |d 50000 |e 50000PS1022937995 |k 0/50000/ |p 5 | ||
| 998 | |g 1155884973 |a Oweira, Hani |m 1155884973:Oweira, Hani |p 2 | ||
| 999 | |a KXP-PPN1581226748 |e 3026403687 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 24.09.2018"],"recId":"1581226748","name":{"displayForm":["Omar Abdel-Rahman, Hani Oweira, Ulf Petrausch, Daniel Helbling, Jan Schmidt, Meinrad Mannhart, Arianeb Mehrabi, Othmar Schöb & Anwar Giryes"]},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"24 Feb 2017"}],"language":["eng"],"person":[{"display":"Abdel-Rahman, Omar M.","role":"aut","family":"Abdel-Rahman","given":"Omar M."},{"display":"Oweira, Hani","role":"aut","family":"Oweira","given":"Hani"},{"given":"Jan","family":"Schmidt","role":"aut","display":"Schmidt, Jan"},{"role":"aut","display":"Mehrabi, Arianeb","given":"Arianeb","family":"Mehrabi"}],"title":[{"title_sort":"Immune-related ocular toxicities in solid tumor patients treated with immune checkpoint inhibitors","title":"Immune-related ocular toxicities in solid tumor patients treated with immune checkpoint inhibitors","subtitle":"a systematic review"}],"relHost":[{"note":["Gesehen am 01.09.15"],"disp":"Immune-related ocular toxicities in solid tumor patients treated with immune checkpoint inhibitors a systematic reviewExpert review of anticancer therapy","physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Expert review of anticancer therapy","title_sort":"Expert review of anticancer therapy"}],"language":["eng"],"origin":[{"publisher":"Taylor & Francis ; Informa Healthcare","dateIssuedDisp":"2001-","publisherPlace":"Abingdon, Oxon ; London","dateIssuedKey":"2001"}],"recId":"355690446","id":{"eki":["355690446"],"issn":["1744-8328"],"zdb":["2090850-7"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"extent":"8","year":"2017","volume":"17","text":"17(2017), 4, Seite 387-394","issue":"4","pages":"387-394"},"pubHistory":["1.2001 -"]}],"physDesc":[{"extent":"8 S."}],"id":{"eki":["1581226748"],"doi":["10.1080/14737140.2017.1296765"]},"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a ABDELRAHMAIMMUNERELA2420 | ||