Modification of membrane lipids protects neurons against insulin resistance in models of Alzheimer's disease
Alzheimer's disease is a degenerative disease of the central nervous system, which leads to severe deficits in memory and orientation by a progressive loss of neurons and synapses. Soluble β-amyloid oligomers are highly neurotoxic precursors of β-amyloid fibrils that accumulate in Alzheimer’s d...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23.11.2017
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| In: |
Neuroforum
Year: 2017, Jahrgang: 23, Heft: 4, Pages: A157-A166 |
| ISSN: | 2363-7013 |
| DOI: | 10.1515/nf-2017-A007 |
| Online-Zugang: | Resolving-System, Volltext: http://dx.doi.org/10.1515/nf-2017-A007 Verlag, Volltext: https://www.degruyterbrill.com/view/j/nf.2017.23.issue-4/nf-2017-A007/nf-2017-A007.xml 
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| Verfasserangaben: | Viola Nordström, Silke Herzer |
| Zusammenfassung: | Alzheimer's disease is a degenerative disease of the central nervous system, which leads to severe deficits in memory and orientation by a progressive loss of neurons and synapses. Soluble β-amyloid oligomers are highly neurotoxic precursors of β-amyloid fibrils that accumulate in Alzheimer’s disease. Binding of β-amyloid oligomers to synaptic insulin receptors leads to neuronal insulin resistance, which significantly contributes to cognitive impairments. |
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| Beschreibung: | Gesehen am 24.09.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 2363-7013 |
| DOI: | 10.1515/nf-2017-A007 |