Functional protease profiling with reporter peptides in serum specimens of colorectal cancer patients: demonstration of its routine diagnostic applicability
The progression of many solid tumors is characterized by the release of tumor-associated proteases and the detection of tumor specific proteolytic activity in serum specimens is a promising diagnostic tool in oncology. Here we describe a mass spectrometry-based functional proteomic profiling approac...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
8 June 2012
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| In: |
Journal of experimental & clinical cancer research
Year: 2012, Volume: 31, Pages: 1-10 |
| ISSN: | 1756-9966 |
| DOI: | 10.1186/1756-9966-31-56 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1756-9966-31-56 Verlag, kostenfrei, Volltext: https://doi.org/10.1186/1756-9966-31-56 
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| Author Notes: | Peter Findeisen, Victor Costina, Diego Yepes, Ralf Hofheinz and Michael Neumaier |
| Summary: | The progression of many solid tumors is characterized by the release of tumor-associated proteases and the detection of tumor specific proteolytic activity in serum specimens is a promising diagnostic tool in oncology. Here we describe a mass spectrometry-based functional proteomic profiling approach that tracks the ex-vivo degradation of a synthetic endoprotease substrate in serum specimens of colorectal tumor patients. |
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| Item Description: | Gesehen am 14.11.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1756-9966 |
| DOI: | 10.1186/1756-9966-31-56 |