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Functional protease profiling with reporter peptides in serum specimens of colorectal cancer patients: demonstration of its routine diagnostic applicability

The progression of many solid tumors is characterized by the release of tumor-associated proteases and the detection of tumor specific proteolytic activity in serum specimens is a promising diagnostic tool in oncology. Here we describe a mass spectrometry-based functional proteomic profiling approac...

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Hauptverfasser: Findeisen, Peter (VerfasserIn) , Costina, Victor (VerfasserIn) , Yepes, Diego (VerfasserIn) , Hofheinz, Ralf-Dieter (VerfasserIn) , Neumaier, Michael (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 8 June 2012
In: Journal of experimental & clinical cancer research
Year: 2012, Jahrgang: 31, Pages: 1-10
ISSN:1756-9966
DOI:10.1186/1756-9966-31-56
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1756-9966-31-56
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/1756-9966-31-56
Volltext
Verfasserangaben:Peter Findeisen, Victor Costina, Diego Yepes, Ralf Hofheinz and Michael Neumaier
Beschreibung
Zusammenfassung:The progression of many solid tumors is characterized by the release of tumor-associated proteases and the detection of tumor specific proteolytic activity in serum specimens is a promising diagnostic tool in oncology. Here we describe a mass spectrometry-based functional proteomic profiling approach that tracks the ex-vivo degradation of a synthetic endoprotease substrate in serum specimens of colorectal tumor patients.
Beschreibung:Gesehen am 14.11.2018
Beschreibung:Online Resource
ISSN:1756-9966
DOI:10.1186/1756-9966-31-56

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