Distinct corticostriatal GABAergic neurons modulate striatal output neurons and motor cctivity
Summary: The motor cortico-basal ganglion loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this loop is crucial for proper motor output. Excitatory neurons have been thought to be the only source of motor cortical input to the striatum. Here, we ide...
Gespeichert in:
| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2 May 2017
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| In: |
Cell reports
Year: 2017, Jahrgang: 19, Heft: 5, Pages: 1045-1055 |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2017.04.024 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.celrep.2017.04.024 Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S2211124717305181 
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| Verfasserangaben: | Sarah Melzer, Mariana Gil, David E. Koser, Magdalena Michael, Kee Wui Huang, Hannah Monyer |
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| 245 | 1 | 0 | |a Distinct corticostriatal GABAergic neurons modulate striatal output neurons and motor cctivity |c Sarah Melzer, Mariana Gil, David E. Koser, Magdalena Michael, Kee Wui Huang, Hannah Monyer |
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| 520 | |a Summary: The motor cortico-basal ganglion loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this loop is crucial for proper motor output. Excitatory neurons have been thought to be the only source of motor cortical input to the striatum. Here, we identify long-range projecting GABAergic neurons in the primary (M1) and secondary (M2) motor cortex that target the dorsal striatum. This population of projecting GABAergic neurons comprises both somatostatin-positive (SOM+) and parvalbumin-positive (PV+) neurons that target direct and indirect pathway striatal output neurons as well as cholinergic interneurons differentially. Notably, optogenetic stimulation of M1 PV+ and M2 SOM+ projecting neurons reduced locomotion, whereas stimulation of M1 SOM+ projecting neurons enhanced locomotion. Thus, corticostriatal GABAergic projections modulate striatal output and motor activity. | ||
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