Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update
Heterotrimeric G proteins are pivotal mediators of cellular signal transduction in eukaryotic cells and abnormal G-protein signaling plays an important role in numerous diseases. During the last two decades it has become evident that the activation status of heterotrimeric G proteins is both highly...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
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| In: |
Laboratory investigation
Year: 2017, Volume: 98, Issue: 2, Pages: 190-197 |
| ISSN: | 1530-0307 |
| DOI: | 10.1038/labinvest.2017.103 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/labinvest.2017.103 Verlag, Volltext: https://www.nature.com/articles/labinvest2017103 
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| Author Notes: | Issam H. Abu-Taha, Jordi Heijman, Yuxi Feng, Christiane Vettel, Dobromir Dobrev and Thomas Wieland |
| Summary: | Heterotrimeric G proteins are pivotal mediators of cellular signal transduction in eukaryotic cells and abnormal G-protein signaling plays an important role in numerous diseases. During the last two decades it has become evident that the activation status of heterotrimeric G proteins is both highly localized and strongly regulated by a number of factors, including a receptor-independent activation pathway of heterotrimeric G proteins that does not involve the classical GDP/GTP exchange and relies on nucleoside diphosphate kinases (NDPKs). NDPKs are NTP/NDP transphosphorylases encoded by the nme/nm23 genes that are involved in a variety of cellular events such as proliferation, migration, and apoptosis. They therefore contribute, for example, to tumor metastasis, angiogenesis, retinopathy, and heart failure. Interestingly, NDPKs are translocated and/or upregulated in human heart failure. Here we describe recent advances in the current understanding of NDPK functions and how they have an impact on local regulation of G-protein signaling. |
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| Item Description: | Published 16 October 2017 Gesehen am 16.11.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1530-0307 |
| DOI: | 10.1038/labinvest.2017.103 |