Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1-mutation as common tumor initiating event
Background: To investigate the dynamics of inter- and intratumoral molecular alterations during tumor progression in recurrent gliomas. Methodology/Principal Findings: To address intertumoral heterogeneity we investigated non- microdissected tumor tissue of 106 gliomas representing 51 recurrent tumo...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 23, 2012
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| In: |
PLOS ONE
Year: 2012, Jahrgang: 7, Heft: 7, Pages: e41298 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0041298 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pone.0041298 Verlag, kostenfrei, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041298 
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| Verfasserangaben: | Ulrike Lass, Astrid Nümann, Kajetan von Eckardstein, Jürgen Kiwit, Florian Stockhammer, Jörn A. Horaczek, Julian Veelken, Christel Herold-Mende, Judith Jeuken, Andreas von Deimling, Wolf Mueller |
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| 245 | 1 | 0 | |a Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1-mutation as common tumor initiating event |c Ulrike Lass, Astrid Nümann, Kajetan von Eckardstein, Jürgen Kiwit, Florian Stockhammer, Jörn A. Horaczek, Julian Veelken, Christel Herold-Mende, Judith Jeuken, Andreas von Deimling, Wolf Mueller |
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| 520 | |a Background: To investigate the dynamics of inter- and intratumoral molecular alterations during tumor progression in recurrent gliomas. Methodology/Principal Findings: To address intertumoral heterogeneity we investigated non- microdissected tumor tissue of 106 gliomas representing 51 recurrent tumors. To address intratumoral heterogeneity a set of 16 gliomas representing 7 tumor pairs with at least one recurrence, and 4 single mixed gliomas were investigated by microdissection of distinct oligodendroglial and astrocytic tumor components. All tumors and tumor components were analyzed for allelic loss of 1p/19q (LOH 1p/19q), for TP53- mutations and for R132 mutations in the IDH1 gene. The investigation of non- microdissected tumor tissue revealed clonality in 75% (38/51). Aberrant molecular alterations upon recurrence were detected in 25% (13/51). 64% (9/14) of these were novel and associated with tumor progression. Loss of previously detected alterations was observed in 36% (5/14). One tumor pair (1/14; 7%) was significant for both. Intratumoral clonality was detected in 57% (4/7) of the microdissected tumor pairs and in 75% (3/4) of single microdissected tumors. 43% (3/7) of tumor pairs and one single tumor (25%) revealed intratumoral heterogeneity. While intratumoral heterogeneity affected both the TP53- mutational status and the LOH1p/19q status, all tumors with intratumoral heterogeneity shared the R132 IDH1- mutation as a common feature in both their microdissected components. Conclusions/Significance: The majority of recurrent gliomas are of monoclonal origin. However, the detection of divertive tumor cell clones in morphological distinct tumor components sharing IDH1- mutations as early event may provide insight into the tumorigenesis of true mixed gliomas. | ||
| 650 | 4 | |a Astrocytoma | |
| 650 | 4 | |a Cloning | |
| 650 | 4 | |a Glioma | |
| 650 | 4 | |a Mutation | |
| 650 | 4 | |a Mutation detection | |
| 650 | 4 | |a Oligodendroglioma | |
| 650 | 4 | |a Somatic mutation | |
| 650 | 4 | |a Surgical oncology | |
| 700 | 1 | |a Herold-Mende, Christel |e VerfasserIn |0 (DE-588)1022936549 |0 (DE-627)717335577 |0 (DE-576)366194267 |4 aut | |
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| 700 | 1 | |a Müller, Wolf C. |d 1967- |e VerfasserIn |0 (DE-588)1075182743 |0 (DE-627)832987476 |0 (DE-576)34814184X |4 aut | |
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