Lenalidomide overcomes the immunosuppression of regulatory CD8 + CD28 - T-cells
We analyzed in vitro the antigen-specific T-cell responses of healthy donors and patients with multiple myeloma with or without the addition of autologous CD8+CD28– T-cells in the absence and presence of lenalidomide. We found that lenalidomide enhances the antigen-specific secretion of IFN-γ and Gr...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 05, 2017
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| In: |
OncoTarget
Year: 2017, Volume: 8, Issue: 58, Pages: 98200-98214 |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.21516 |
| Online Access: | Resolving-System, kostenfrei, Volltext: http://dx.doi.org/10.18632/oncotarget.21516 Verlag, kostenfrei, Volltext: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=21516&path[]=68369 
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| Author Notes: | Brigitte Neuber, Jingying Dai, Wjahat A. Waraich, Mohamed H. S. Awwad, Melanie Engelhardt, Michael Schmitt, Sergej Medenhoff, Mathias Witzens-Harig, Anthony D. Ho, Hartmut Goldschmidt, Michael Hundemer, Brigitte Neuber, Jingying Dai, Wjahat A. Waraich, Mohamed H. S. Awwad, Melanie Engelhardt, Michael Schmitt, Sergej Medenhoff, Mathias Witzens-Harig, Anthony D. Ho, Hartmut Goldschmidt and Michael Hundemer |
| Summary: | We analyzed in vitro the antigen-specific T-cell responses of healthy donors and patients with multiple myeloma with or without the addition of autologous CD8+CD28– T-cells in the absence and presence of lenalidomide. We found that lenalidomide enhances the antigen-specific secretion of IFN-γ and Granzyme B despite the addition of CD8+CD28– T-cells. Furthermore, we showed that lenalidomide inhibits the IL-6 secretion of mononuclear cells, triggered by CD8+CD28– T-cells. |
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| Item Description: | Gesehen am 28.09.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.21516 |