PML promotes MHC class II gene expression by stabilizing the class II transactivator
Promyelocytic leukemia (PML) nuclear bodies selectively associate with transcriptionally active genomic regions, including the gene-rich major histocompatibility (MHC) locus. In this paper, we have explored potential links between PML and interferon (IFN)-γ-induced MHC class II expression. IFN-γ ind...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 September, 2012
|
| In: |
The journal of cell biology
Year: 2012, Jahrgang: 199, Heft: 1, Pages: 49-63 |
| ISSN: | 1540-8140 |
| DOI: | 10.1083/jcb.201112015 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1083/jcb.201112015 Verlag, kostenfrei, Volltext: http://jcb.rupress.org/content/199/1/49 
|
| Verfasserangaben: | Tobias Ulbricht, Mohammad Alzrigat, Almut Horch, Nina Reuter, Anna von Mikecz, Viktor Steimle, Eberhard Schmitt, Oliver H. Krämer, Thomas Stamminger, and Peter Hemmerich |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1581424531 | ||
| 003 | DE-627 | ||
| 005 | 20220815022507.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180928s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1083/jcb.201112015 |2 doi | |
| 035 | |a (DE-627)1581424531 | ||
| 035 | |a (DE-576)511424531 | ||
| 035 | |a (DE-599)BSZ511424531 | ||
| 035 | |a (OCoLC)1341019489 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 30 |2 sdnb | ||
| 100 | 1 | |a Ulbricht, Tobias |d 1980- |e VerfasserIn |0 (DE-588)1011700999 |0 (DE-627)704796783 |0 (DE-576)343527022 |4 aut | |
| 245 | 1 | 0 | |a PML promotes MHC class II gene expression by stabilizing the class II transactivator |c Tobias Ulbricht, Mohammad Alzrigat, Almut Horch, Nina Reuter, Anna von Mikecz, Viktor Steimle, Eberhard Schmitt, Oliver H. Krämer, Thomas Stamminger, and Peter Hemmerich |
| 264 | 1 | |c 24 September, 2012 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.09.2018 | ||
| 520 | |a Promyelocytic leukemia (PML) nuclear bodies selectively associate with transcriptionally active genomic regions, including the gene-rich major histocompatibility (MHC) locus. In this paper, we have explored potential links between PML and interferon (IFN)-γ-induced MHC class II expression. IFN-γ induced a substantial increase in the spatial proximity between PML bodies and the MHC class II gene cluster in different human cell types. Knockdown experiments show that PML is required for efficient IFN-γ-induced MHC II gene transcription through regulation of the class II transactivator (CIITA). PML mediates this function through protection of CIITA from proteasomal degradation. We also show that PML isoform II specifically forms a stable complex with CIITA at PML bodies. These observations establish PML as a coregulator of IFN-γ-induced MHC class II expression. | ||
| 700 | 1 | |a Schmitt, Eberhard |d 19XX- |e VerfasserIn |0 (DE-588)1164177958 |0 (DE-627)102864096X |0 (DE-576)508415578 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of cell biology |d New York, NY : Rockefeller Univ. Press, 1962 |g 199(2012), 1, Seite 49-63 |h Online-Ressource |w (DE-627)242065244 |w (DE-600)1421310-2 |w (DE-576)065026527 |x 1540-8140 |7 nnas |a PML promotes MHC class II gene expression by stabilizing the class II transactivator |
| 773 | 1 | 8 | |g volume:199 |g year:2012 |g number:1 |g pages:49-63 |g extent:15 |a PML promotes MHC class II gene expression by stabilizing the class II transactivator |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1083/jcb.201112015 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://jcb.rupress.org/content/199/1/49 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180928 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1164177958 |a Schmitt, Eberhard |m 1164177958:Schmitt, Eberhard |d 130000 |d 130700 |e 130000PS1164177958 |e 130700PS1164177958 |k 0/130000/ |k 1/130000/130700/ |p 7 | ||
| 999 | |a KXP-PPN1581424531 |e 302743506X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"15 S."}],"relHost":[{"origin":[{"dateIssuedKey":"1962","publisher":"Rockefeller Univ. Press","dateIssuedDisp":"1962-","publisherPlace":"New York, NY"}],"id":{"issn":["1540-8140"],"eki":["242065244"],"zdb":["1421310-2"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"journal of cell biology","title":"The journal of cell biology","subtitle":"JCB"}],"pubHistory":["12.1962 -"],"titleAlt":[{"title":"JCB"},{"title":"Cell biology"}],"part":{"pages":"49-63","issue":"1","year":"2012","extent":"15","volume":"199","text":"199(2012), 1, Seite 49-63"},"note":["Gesehen am 04.06.20"],"disp":"PML promotes MHC class II gene expression by stabilizing the class II transactivatorThe journal of cell biology","type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"recId":"242065244"}],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"24 September, 2012"}],"id":{"eki":["1581424531"],"doi":["10.1083/jcb.201112015"]},"name":{"displayForm":["Tobias Ulbricht, Mohammad Alzrigat, Almut Horch, Nina Reuter, Anna von Mikecz, Viktor Steimle, Eberhard Schmitt, Oliver H. Krämer, Thomas Stamminger, and Peter Hemmerich"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 28.09.2018"],"language":["eng"],"recId":"1581424531","title":[{"title":"PML promotes MHC class II gene expression by stabilizing the class II transactivator","title_sort":"PML promotes MHC class II gene expression by stabilizing the class II transactivator"}],"person":[{"display":"Ulbricht, Tobias","roleDisplay":"VerfasserIn","role":"aut","family":"Ulbricht","given":"Tobias"},{"display":"Schmitt, Eberhard","roleDisplay":"VerfasserIn","role":"aut","family":"Schmitt","given":"Eberhard"}]} | ||
| SRT | |a ULBRICHTTOPMLPROMOTE2420 | ||