Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke
Hypoxia-inducible factors mediate adaptive responses to ischemia, among others, by induction of anti- and pro-survival genes. Thus, the impact of HIF on neuronal survival upon stroke is controversial. Therefore, neuron-specific knockout mice deficient for Hif1a and Hif2a were exposed to inspiratory...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
|
| In: |
Journal of critical care
Year: 2016, Volume: 37, Issue: 1, Pages: 291-306 |
| ISSN: | 1557-8615 |
| DOI: | 10.1177/0271678X15624933 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1177/0271678X15624933 Verlag, Volltext: https://doi.org/10.1177/0271678X15624933 
|
| Author Notes: | Philipp Barteczek, Lexiao Li, Anne-Sophie Ernst, Laura-Inés Böhler, Hugo H Marti and Reiner Kunze |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1581440197 | ||
| 003 | DE-627 | ||
| 005 | 20220815022554.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181001r20172016xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/0271678X15624933 |2 doi | |
| 035 | |a (DE-627)1581440197 | ||
| 035 | |a (DE-576)511440197 | ||
| 035 | |a (DE-599)BSZ511440197 | ||
| 035 | |a (OCoLC)1341019505 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Barteczek, Philipp |e VerfasserIn |0 (DE-588)1168168600 |0 (DE-627)1031807136 |0 (DE-576)511442475 |4 aut | |
| 245 | 1 | 0 | |a Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke |c Philipp Barteczek, Lexiao Li, Anne-Sophie Ernst, Laura-Inés Böhler, Hugo H Marti and Reiner Kunze |
| 246 | 3 | 3 | |a Neuronal HIF-1 alpha and HIF-2 alpha deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke |
| 264 | 1 | |c 2017 | |
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Received: July 21, 2015; Revisions received: October 30, 2015; Accepted: December 07, 2015; First Published January 8, 2016 | ||
| 500 | |a Gesehen am 01.10.2018 | ||
| 520 | |a Hypoxia-inducible factors mediate adaptive responses to ischemia, among others, by induction of anti- and pro-survival genes. Thus, the impact of HIF on neuronal survival upon stroke is controversial. Therefore, neuron-specific knockout mice deficient for Hif1a and Hif2a were exposed to inspiratory hypoxia or ischemia-reperfusion injury. Both Hif1a- and Hif2a-deficient mice showed no altered infarct and edema size, suggesting that both HIF-α subunits might compensate for each other. Accordingly, hypoxic HIF-target gene regulation was marginally affected with exception of anti-survival Bnip3 and pro-survival erythropoietin. In the early acute stage upon stroke, Hif1a/Hif2a double knockout mice exhibited significantly reduced expression of the anti-survival Bnip3, Bnip3L, and Pmaip1. Accordingly, global cell death and edema were significantly reduced upon 24 h but not 72 h reperfusion. Behavioral assessment indicated that Hif1a/Hif2a-deficient mice initially performed better, but became significantly more impaired after 72 h accompanied by increased apoptosis and reduced angiogenesis. Our findings suggest that in neurons HIF-1 and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a/Hif2a-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke. | ||
| 534 | |c 2016 | ||
| 700 | 1 | |a Li, Lexiao |e VerfasserIn |0 (DE-588)1129289893 |0 (DE-627)883906953 |0 (DE-576)486317625 |4 aut | |
| 700 | 1 | |a Ernst, Anne-Sophie |e VerfasserIn |0 (DE-588)1167521455 |0 (DE-627)1031152563 |0 (DE-576)511172729 |4 aut | |
| 700 | 1 | |a Böhler, Laura-Inés |e VerfasserIn |0 (DE-588)1125974303 |0 (DE-627)880574208 |0 (DE-576)483672602 |4 aut | |
| 700 | 1 | |a Marti, Hugo |e VerfasserIn |0 (DE-588)1137018356 |0 (DE-627)893957208 |0 (DE-576)491045468 |4 aut | |
| 700 | 1 | |a Kunze, Reiner |d 1980- |e VerfasserIn |0 (DE-588)141152494 |0 (DE-627)62540128X |0 (DE-576)321552504 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of critical care |d [Amsterdam] : Elsevier, 1986 |g 37(2017), 1, Seite 291-306 |h Online-Ressource |w (DE-627)326646167 |w (DE-600)2041640-4 |w (DE-576)096188820 |x 1557-8615 |7 nnas |a Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke |
| 773 | 1 | 8 | |g volume:37 |g year:2017 |g number:1 |g pages:291-306 |g extent:16 |a Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1177/0271678X15624933 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1177/0271678X15624933 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181001 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 141152494 |a Kunze, Reiner |m 141152494:Kunze, Reiner |d 50000 |d 53200 |e 50000PK141152494 |e 53200PK141152494 |k 0/50000/ |k 1/50000/53200/ |p 6 |y j | ||
| 998 | |g 1137018356 |a Marti, Hugo |m 1137018356:Marti, Hugo |d 50000 |d 53200 |e 50000PM1137018356 |e 53200PM1137018356 |k 0/50000/ |k 1/50000/53200/ |p 5 | ||
| 998 | |g 1125974303 |a Böhler, Laura-Inés |m 1125974303:Böhler, Laura-Inés |d 50000 |d 53200 |e 50000PB1125974303 |e 53200PB1125974303 |k 0/50000/ |k 1/50000/53200/ |p 4 | ||
| 998 | |g 1167521455 |a Ernst, Anne-Sophie |m 1167521455:Ernst, Anne-Sophie |d 140000 |e 140000PE1167521455 |k 0/140000/ |p 3 | ||
| 998 | |g 1129289893 |a Li, Lexiao |m 1129289893:Li, Lexiao |d 140000 |e 140000PL1129289893 |k 0/140000/ |p 2 | ||
| 998 | |g 1168168600 |a Barteczek, Philipp |m 1168168600:Barteczek, Philipp |d 50000 |e 50000PB1168168600 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1581440197 |e 3027465732 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Received: July 21, 2015; Revisions received: October 30, 2015; Accepted: December 07, 2015; First Published January 8, 2016","Gesehen am 01.10.2018"],"recId":"1581440197","language":["eng"],"titleAlt":[{"title":"Neuronal HIF-1 alpha and HIF-2 alpha deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke"}],"person":[{"family":"Barteczek","given":"Philipp","display":"Barteczek, Philipp","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Lexiao","family":"Li","role":"aut","display":"Li, Lexiao","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Ernst, Anne-Sophie","roleDisplay":"VerfasserIn","given":"Anne-Sophie","family":"Ernst"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Böhler, Laura-Inés","given":"Laura-Inés","family":"Böhler"},{"role":"aut","display":"Marti, Hugo","roleDisplay":"VerfasserIn","given":"Hugo","family":"Marti"},{"given":"Reiner","family":"Kunze","role":"aut","roleDisplay":"VerfasserIn","display":"Kunze, Reiner"}],"title":[{"title_sort":"Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke","title":"Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke"}],"physDesc":[{"extent":"16 S."}],"relHost":[{"pubHistory":["1.1986 -"],"part":{"issue":"1","pages":"291-306","year":"2017","extent":"16","text":"37(2017), 1, Seite 291-306","volume":"37"},"note":["Gesehen am 20.08.2020"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic strokeJournal of critical care","recId":"326646167","language":["eng"],"title":[{"title":"Journal of critical care","title_sort":"Journal of critical care"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"1986-","publisher":"Elsevier ; Saunders","dateIssuedKey":"1986","publisherPlace":"[Amsterdam] ; Philadelphia, Pa."}],"id":{"issn":["1557-8615"],"eki":["326646167"],"zdb":["2041640-4"]}}],"name":{"displayForm":["Philipp Barteczek, Lexiao Li, Anne-Sophie Ernst, Laura-Inés Böhler, Hugo H Marti and Reiner Kunze"]},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"2017"}],"id":{"eki":["1581440197"],"doi":["10.1177/0271678X15624933"]}} | ||
| SRT | |a BARTECZEKPNEURONALHI2017 | ||