Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients
Abnormal activation of brain microglial cells is widely implicated in the pathogenesis of schizophrenia. Previously the pathophysiology of microglial activation was considered to be intrinsic to the central nervous system. We hypothesised that due to their perivascular localization, microglia can al...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
|
| In: |
Brain, behavior and immunity
Year: 2017, Volume: 67, Pages: 364-373 |
| ISSN: | 1090-2139 |
| DOI: | 10.1016/j.bbi.2017.10.003 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.bbi.2017.10.003 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0889159117304567 
|
| Author Notes: | Geertje Frederique van Rees, Santiago Guillermo Lago, David Alan Cox, Jakub Tomasik, Nitin Rustogi, Karin Weigelt, Sureyya Ozcan, Jason Cooper, Hemmo Drexhage, F. Markus Leweke, Sabine Bahn |
| Summary: | Abnormal activation of brain microglial cells is widely implicated in the pathogenesis of schizophrenia. Previously the pathophysiology of microglial activation was considered to be intrinsic to the central nervous system. We hypothesised that due to their perivascular localization, microglia can also be activated by factors present in circulating blood. Through application of high-content functional screening, we show that peripheral blood serum from first-onset drug-naïve schizophrenia patients is sufficient to provoke microglial cell signalling network responses in vitro which are indicative of proinflammatory activation. We further explore the composition of the serum for the presence of analytes, with the potential to activate microglia, and the utility of the resultant microglial cellular phenotype for novel drug discovery. |
|---|---|
| Item Description: | Available online 4 October 2017 Gesehen am 01.10.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1090-2139 |
| DOI: | 10.1016/j.bbi.2017.10.003 |