Fibroid explants reveal a higher sensitivity against MDM2-inhibitor nutlin-3 than matching myometrium
Spontaneous cessation of growth is a frequent finding in uterine fibroids. Increasing evidence suggests an important role of cellular senescence in this growth control. Deciphering the underlying mechanisms of growth control that can be expected not only to shed light on the biology of the tumors bu...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 January 2012
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| In: |
BMC women's health
Year: 2012, Jahrgang: 12 |
| ISSN: | 1472-6874 |
| DOI: | 10.1186/1472-6874-12-2 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1472-6874-12-2 Verlag, Volltext: https://doi.org/10.1186/1472-6874-12-2 
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| Verfasserangaben: | Dominique N. Markowski, Burkhard M. Helmke, Arlo Radtke, Jennifer Froeb, Gazanfer Belge, Sabine Bartnitzke, Werner Wosniok, Iris Czybulka-Jachertz, Ulrich Deichert and Jörn Bullerdiek |
| Zusammenfassung: | Spontaneous cessation of growth is a frequent finding in uterine fibroids. Increasing evidence suggests an important role of cellular senescence in this growth control. Deciphering the underlying mechanisms of growth control that can be expected not only to shed light on the biology of the tumors but also to identify novel therapeutic targets. |
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| Beschreibung: | Gesehen am 04.10.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1472-6874 |
| DOI: | 10.1186/1472-6874-12-2 |