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Kinetic analysis reveals successive steps leading to miRNA‐mediated silencing in mammalian cells

MicroRNAs (miRNAs) regulate most cellular functions, acting by posttranscriptionally repressing numerous eukaryotic mRNAs. They lead to translational repression, deadenylation and degradation of their target mRNAs. Yet, the relative contributions of these effects are controversial and little is know...

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Hauptverfasser: Béthune, Julien (VerfasserIn) , Artus-Revel, Caroline (VerfasserIn) , Filipowicz, Witold (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 8 June 2012
In: EMBO reports
Year: 2012, Jahrgang: 13, Heft: 8, Pages: 716-723
ISSN:1469-3178
DOI:10.1038/embor.2012.82
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1038/embor.2012.82
Verlag, Volltext: http://embor.embopress.org/content/13/8/716
Volltext
Verfasserangaben:Julien Béthune, Caroline G. Artus‐Revel, Witold Filipowicz

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