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Antibiotic coating of the artificial urinary sphincter (AMS 800): is it worthwhile?

Objective: To investigate the impact of the antibiotic coating InhibiZone on the infection and explantation rates of the AMS 800 in comparison to the AMS 800 without InhibiZone. Materials and Methods: We retrospectively identified 305 patients with an AMS 800 in a multicenter cohort study. Patients...

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Hauptverfasser: Hüsch, Tanja (VerfasserIn) , Nyarangi-Dix, Joanne (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2017
In: Urology
Year: 2017, Jahrgang: 103, Pages: 179-184
ISSN:1527-9995
DOI:10.1016/j.urology.2016.12.056
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/j.urology.2016.12.056
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0090429517300298
Volltext
Verfasserangaben:Tanja Hüsch, Alexander Kretschmer, Frauke Thomsen, Dominik Kronlachner, Martin Kurosch, Alice Obaje, Ralf Anding, Tobias Pottek, Achim Rose, Roberto Olianas, Alexander Friedl, Wilhelm Hübner, Roland Homberg, Jesco Pfitzenmaier, Ulrich Grein, Fabian Queissert, Carsten M. Naumann, Josef Schweiger, Carola Wotzka, Joanne Nyarangi-Dix, Torben Hofmann, Kurt Ulm, Ricarda M. Bauer, Axel Haferkamp

MARC

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520 |a Objective: To investigate the impact of the antibiotic coating InhibiZone on the infection and explantation rates of the AMS 800 in comparison to the AMS 800 without InhibiZone. Materials and Methods: We retrospectively identified 305 patients with an AMS 800 in a multicenter cohort study. Patients were subsequently divided into InhibiZone and without InhibiZone-coated groups. Infection and explantation rates were analyzed by univariate and consecutively by multivariate logistic regression adjusted to variable risk factors. The infection-free interval was estimated by Kaplan-Meier plot and compared by the log-rank test. A P value below .05 was considered statistically significant. Results: We identified 47 patients with InhibiZone and 258 without InhibiZone coating. In univariate analysis, we could not identify a significant difference in infection (P = .932) or explantation (P = .715) rates between the groups. In multivariate analysis, impaired wound healing (P = .008) and urethral erosion (P < .001) were independent predictors for infection. The InhibiZone coating neither demonstrated significant influence on the infection rate (P = .534) nor on the explantation rate (P = .214). There was no significant difference in estimated infection-free survival between the groups (P = .265). Conclusion: The antibiotic coating of the AMS 800 had no significant impact on infection or explantation rates in our cohort. 
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