Proarrhythmic atrial calcium cycling in the diseased heart
During the last decades Ca2+ has been found to play a crucial role in cardiac arrhythmias associated with heart failure and a number of congenital arrhythmia syndromes. Recent studies demonstrated that altered atrial Ca2+ cycling may promote the initiation and maintenance of atrial fibrillation, the...
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| Main Authors: | , , |
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| Format: | Chapter/Article |
| Language: | English |
| Published: |
14 February 2012
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| In: |
Calcium signaling
Year: 2012, Pages: 1175-1191 |
| DOI: | 10.1007/978-94-007-2888-2_53 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/978-94-007-2888-2_53 Verlag, Volltext: https://doi.org/10.1007/978-94-007-2888-2_53 
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| Author Notes: | Niels Voigt, Stanley Nattel, Dobromir Dobrev |
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| 520 | |a During the last decades Ca2+ has been found to play a crucial role in cardiac arrhythmias associated with heart failure and a number of congenital arrhythmia syndromes. Recent studies demonstrated that altered atrial Ca2+ cycling may promote the initiation and maintenance of atrial fibrillation, the most common clinical arrhythmia that contributes significantly to population morbidity and mortality. This article describes physiological Ca2+ cycling mechanisms in atrial cardiomyocytes and relates them to fundamental cellular proarrhythmic mechanisms involving Ca2+ signaling abnormalities in the atrium during atrial fibrillation. | ||
| 650 | 4 | |a Atrial arrhythmias | |
| 650 | 4 | |a Calcium | |
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