Enteric-coated mycophenolate sodium immunosuppression in renal transplant patients: efficacy and dosing

Mycophenolate mofetil (MMF), a mycophenolic acid (MPA) formulation, has improved both short- and long-term outcomes following renal transplantation, but is often associated with gastrointestinal (GI) complications that can lead to dose reduction or discontinuation, potentially jeopardizing patient o...

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Hauptverfasser: Cooper, Matthew A. (VerfasserIn) , Zeier, Martin (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: October 2012
In: Transplantation reviews
Year: 2012, Jahrgang: 26, Heft: 4, Pages: 233-240
ISSN:1557-9816
DOI:10.1016/j.trre.2012.02.001
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/j.trre.2012.02.001
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0955470X12000158
Volltext
Verfasserangaben:Matthew Cooper, Maurizio Salvadori, Klemens Budde, Frederic Oppenheimer, Hans Sollinger, Martin Zeier

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520 |a Mycophenolate mofetil (MMF), a mycophenolic acid (MPA) formulation, has improved both short- and long-term outcomes following renal transplantation, but is often associated with gastrointestinal (GI) complications that can lead to dose reduction or discontinuation, potentially jeopardizing patient outcomes. Enteric-coated mycophenolate sodium (EC-MPS) delivers equivalent MPA exposure to MMF and offers the potential to reduce GI burden (while maintaining patient safety). Here we review the efficacy of EC-MPS compared with MMF in renal transplant patients in terms of biopsy-proven acute rejection and graft loss, and examine the use of EC-MPS in newer regimens such as intensified dosing and calcineurin inhibitor minimization. 
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