Computed tomography perfusion imaging for monitoring transarterial chemoembolization of hepatocellular carcinoma
Purpose: To prospectively monitor changes in tumor perfusion of hepatocellular carcinoma (HCC) in response to doxorubicin-eluted bead based transarterial chemoembolization (DEB-TACE) using perfusion-CT (P-CT). Methods and materials: 24 patients (54-79 years) undergoing P-CT before and shortly after...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 March 2017
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| In: |
European journal of radiology
Year: 2017, Jahrgang: 91, Pages: 160-167 |
| ISSN: | 1872-7727 |
| DOI: | 10.1016/j.ejrad.2017.03.014 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.ejrad.2017.03.014 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0720048X17301146 
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| Verfasserangaben: | Herman P. Marquez, Amar Karalli, Holger Haubenreisser, Rishi P. Mathew, Hatem Alkadhi, Torkel B. Brismar, Thomas Henzler, Michael A. Fischer |
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| 245 | 1 | 0 | |a Computed tomography perfusion imaging for monitoring transarterial chemoembolization of hepatocellular carcinoma |c Herman P. Marquez, Amar Karalli, Holger Haubenreisser, Rishi P. Mathew, Hatem Alkadhi, Torkel B. Brismar, Thomas Henzler, Michael A. Fischer |
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| 520 | |a Purpose: To prospectively monitor changes in tumor perfusion of hepatocellular carcinoma (HCC) in response to doxorubicin-eluted bead based transarterial chemoembolization (DEB-TACE) using perfusion-CT (P-CT). Methods and materials: 24 patients (54-79 years) undergoing P-CT before and shortly after DEB-TACE of HCC were prospectively included in this dual-center study. Two readers determined arterial-liver-perfusion (ALP, mL/min/100mL), portal-venous-perfusion (PLP, mL/min/100mL) and the hepatic-perfusion-index (HPI, %) by placing matched regions-of-interests within each HCC before and after DEB-TACE. Imaging follow-up was used to determine treatment response and to distinguish complete from incomplete responders. Performance of P-CT for prediction and early response assessment was determined using receiver-operating-characteristics curve analysis. Results: Interreader agreement was fair to excellent (ICC, 0.716-0.942). PLP before DEB-TACE was significantly higher in pre-treated vs non-treated lesions (P<0.05). Mean changes of ALP, PLP and HPI from before to after DEB-TACE were −55%, +24% and −27%. ALP and HPI after DEB-TACE were correlating with response-grades (r=0.45/0.48; both, p<0.04), showing an area-under-the-curve (AUC) of 0.74 and 0.80 respectively for identification of complete response. Conclusion: High arterial and low portal-venous perfusion of HCC early after DEB-TACE indicates incomplete response with good diagnostic accuracy. | ||
| 650 | 4 | |a Computed tomography | |
| 650 | 4 | |a Hepatocellular carcinoma | |
| 650 | 4 | |a Perfusion imaging | |
| 650 | 4 | |a Transarterial chemoembolization | |
| 650 | 4 | |a Treatment outcome | |
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