Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes
Overexpression of MN1, ERG, BAALC, and EVI1 (MEBE) genes in cytogenetically normal acute myeloid leukemia (AML) patients is associated with poor prognosis, but their prognostic effect in patients with myelodysplastic syndromes (MDS) has not been studied systematically. Expression data of the four ge...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 April 2012
|
| In: |
Annals of hematology
Year: 2012, Jahrgang: 91, Heft: 8, Pages: 1221-1233 |
| ISSN: | 1432-0584 |
| DOI: | 10.1007/s00277-012-1457-7 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s00277-012-1457-7 Verlag, Volltext: https://doi.org/10.1007/s00277-012-1457-7 
|
| Verfasserangaben: | Felicitas Thol, Haiyang Yun, Ann-Kathrin Sonntag, Frederik Damm, Eva M. Weissinger, Jürgen Krauter, Katharina Wagner, Michael Morgan, Martin Wichmann, Gudrun Göhring, Gesine Bug, Oliver Ottmann, Wolf-Karsten Hofmann, Axel Schambach, Brigitte Schlegelberger, Torsten Haferlach, David Bowen, Ken Mills, Arnold Ganser, Michael Heuser |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1581853920 | ||
| 003 | DE-627 | ||
| 005 | 20220815030719.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181012s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00277-012-1457-7 |2 doi | |
| 035 | |a (DE-627)1581853920 | ||
| 035 | |a (DE-576)511853920 | ||
| 035 | |a (DE-599)BSZ511853920 | ||
| 035 | |a (OCoLC)1341019930 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Thol, Felicitas |d 1977- |e VerfasserIn |0 (DE-588)129633984 |0 (DE-627)475217403 |0 (DE-576)297759329 |4 aut | |
| 245 | 1 | 0 | |a Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes |c Felicitas Thol, Haiyang Yun, Ann-Kathrin Sonntag, Frederik Damm, Eva M. Weissinger, Jürgen Krauter, Katharina Wagner, Michael Morgan, Martin Wichmann, Gudrun Göhring, Gesine Bug, Oliver Ottmann, Wolf-Karsten Hofmann, Axel Schambach, Brigitte Schlegelberger, Torsten Haferlach, David Bowen, Ken Mills, Arnold Ganser, Michael Heuser |
| 264 | 1 | |c 10 April 2012 | |
| 300 | |b Diagramme | ||
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.10.2018 | ||
| 520 | |a Overexpression of MN1, ERG, BAALC, and EVI1 (MEBE) genes in cytogenetically normal acute myeloid leukemia (AML) patients is associated with poor prognosis, but their prognostic effect in patients with myelodysplastic syndromes (MDS) has not been studied systematically. Expression data of the four genes from 140 MDS patients were combined in an additive score, which was validated in an independent patient cohort of 110 MDS patients. A high MEBE score, defined as high expression of at least two of the four genes, predicted a significantly shorter overall survival (OS) (HR 2.29, 95 % CI 1.3-4.09, P = .005) and time to AML progression (HR 4.83, 95 % CI 2.01-11.57, P < .001) compared to a low MEBE score in multivariate analysis independent of karyotype, percentage of bone marrow blasts, transfusion dependence, ASXL1, and IDH1 mutation status. In a validation cohort of 110 MDS patients, a high MEBE score predicted shorter OS (HR 1.77; 95 % CI 1.04-3.0, P = .034) and time to AML progression (HR 3.0, 95 % CI 1.17-7.65, P = .022). A high MEBE expression score is an unfavorable prognostic marker in MDS and is associated with an increased risk for progression to AML. Expression of the MEBE genes is regulated by FLI1 and c-MYC, which are potential upstream targets of the MEBE signature. | ||
| 650 | 4 | |a Gene expression | |
| 650 | 4 | |a MDS | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Score | |
| 650 | 4 | |a Splicing | |
| 700 | 1 | |a Hofmann, Wolf-Karsten |d 1967- |e VerfasserIn |0 (DE-588)114154635 |0 (DE-627)691208751 |0 (DE-576)351568336 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of hematology |d Berlin : Springer, 1991 |g 91(2012), 8, Seite 1221-1233 |h Online-Ressource |w (DE-627)253389852 |w (DE-600)1458429-3 |w (DE-576)072283157 |x 1432-0584 |7 nnas |a Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes |
| 773 | 1 | 8 | |g volume:91 |g year:2012 |g number:8 |g pages:1221-1233 |g extent:13 |a Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00277-012-1457-7 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00277-012-1457-7 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181012 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 114154635 |a Hofmann, Wolf-Karsten |m 114154635:Hofmann, Wolf-Karsten |d 60000 |d 61200 |e 60000PH114154635 |e 61200PH114154635 |k 0/60000/ |k 1/60000/61200/ |p 13 | ||
| 999 | |a KXP-PPN1581853920 |e 3028660768 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"title":[{"title_sort":"Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes","title":"Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes"}],"person":[{"role":"aut","family":"Thol","display":"Thol, Felicitas","given":"Felicitas"},{"role":"aut","family":"Hofmann","display":"Hofmann, Wolf-Karsten","given":"Wolf-Karsten"}],"recId":"1581853920","name":{"displayForm":["Felicitas Thol, Haiyang Yun, Ann-Kathrin Sonntag, Frederik Damm, Eva M. Weissinger, Jürgen Krauter, Katharina Wagner, Michael Morgan, Martin Wichmann, Gudrun Göhring, Gesine Bug, Oliver Ottmann, Wolf-Karsten Hofmann, Axel Schambach, Brigitte Schlegelberger, Torsten Haferlach, David Bowen, Ken Mills, Arnold Ganser, Michael Heuser"]},"origin":[{"dateIssuedDisp":"10 April 2012","dateIssuedKey":"2012"}],"relHost":[{"title":[{"title":"Annals of hematology","subtitle":"organ of: Gesellschaft für Thrombose- und Hämostaseforschung, DGHO, Deutsche Gesellschaft für Hämatologie und Onkologie e.V., ÖGHO, Österreichische Gesellschaft für Hämatologie und Onkologie","title_sort":"Annals of hematology"}],"origin":[{"dateIssuedKey":"1991","publisherPlace":"Berlin ; Heidelberg ; New York","publisher":"Springer","dateIssuedDisp":"1991-"}],"note":["Gesehen am 24.04.2025","Fortsetzung der Druck-Ausgabe","Ungezählte Beil. ab 80.2001: Supplement"],"id":{"issn":["1432-0584"],"zdb":["1458429-3"],"eki":["253389852"]},"part":{"extent":"13","issue":"8","text":"91(2012), 8, Seite 1221-1233","volume":"91","year":"2012","pages":"1221-1233"},"physDesc":[{"extent":"Online-Ressource"}],"titleAlt":[{"title":"Hematology"}],"language":["eng"],"recId":"253389852","disp":"Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromesAnnals of hematology","pubHistory":["62, 1 (Februrary 1991)-"],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"note":["Gesehen am 12.10.2018"],"physDesc":[{"extent":"13 S.","noteIll":"Diagramme"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1581853920"],"doi":["10.1007/s00277-012-1457-7"]}} | ||
| SRT | |a THOLFELICIPROGNOSTIC1020 | ||