Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies
Quantification of minimal residual disease (MRD) by real-time PCR directed to TCR and Ig gene rearrangements allows a refined evaluation of response in acute lymphoblastic leukemia (ALL). The German Multicenter Study Group for Adult ALL prospectively evaluated molecular response after induction/cons...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 30, 2012
|
| In: |
Blood
Year: 2012, Jahrgang: 120, Heft: 9, Pages: 1868-1876 |
| ISSN: | 1528-0020 |
| DOI: | 10.1182/blood-2011-09-377713 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1182/blood-2011-09-377713 Verlag, Volltext: http://www.bloodjournal.org/content/120/9/1868 
|
| Verfasserangaben: | Nicola Gökbuget, Michael Kneba, Thorsten Raff, Heiko Trautmann, Claus-Rainer Bartram, Renate Arnold, Rainer Fietkau, Mathias Freund, Arnold Ganser, Wolf-Dieter Ludwig, Georg Maschmeyer, Harald Rieder, Stefan Schwartz, Hubert Serve, Eckhard Thiel, Monika Brüggemann, and Dieter Hoelzer, on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1581946767 | ||
| 003 | DE-627 | ||
| 005 | 20220815032019.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181016s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1182/blood-2011-09-377713 |2 doi | |
| 035 | |a (DE-627)1581946767 | ||
| 035 | |a (DE-576)511946767 | ||
| 035 | |a (DE-599)BSZ511946767 | ||
| 035 | |a (OCoLC)1341020071 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Gökbuget, Nicola |e VerfasserIn |0 (DE-588)11298407X |0 (DE-627)52917541X |0 (DE-576)168336537 |4 aut | |
| 245 | 1 | 0 | |a Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies |c Nicola Gökbuget, Michael Kneba, Thorsten Raff, Heiko Trautmann, Claus-Rainer Bartram, Renate Arnold, Rainer Fietkau, Mathias Freund, Arnold Ganser, Wolf-Dieter Ludwig, Georg Maschmeyer, Harald Rieder, Stefan Schwartz, Hubert Serve, Eckhard Thiel, Monika Brüggemann, and Dieter Hoelzer, on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia |
| 264 | 1 | |c August 30, 2012 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a First Edition: March 22, 2012 | ||
| 500 | |a Gesehen am 16.10.2018 | ||
| 520 | |a Quantification of minimal residual disease (MRD) by real-time PCR directed to TCR and Ig gene rearrangements allows a refined evaluation of response in acute lymphoblastic leukemia (ALL). The German Multicenter Study Group for Adult ALL prospectively evaluated molecular response after induction/consolidation chemotherapy according to standardized methods and terminology in patients with Philadelphia chromosome-negative ALL. The cytologic complete response (CR) rate was 89% after induction phases 1 and 2. At this time point the molecular CR rate was 70% in 580 patients with cytologic CR and evaluable MRD. Patients with molecular CR after consolidation had a significantly higher probability of continuous complete remission (CCR; 74% vs 35%; P < .0001) and of overall survival (80% vs 42%; P = .0001) compared with patients with molecular failure. Patients with molecular failure without stem cell transplantation (SCT) in first CR relapsed after a median time of 7.6 months; CCR and survival at 5 years only reached 12% and 33%, respectively. Quantitative MRD assessment identified patients with molecular failure as a new high-risk group. These patients display resistance to conventional drugs and are candidates for treatment with targeted, experimental drugs and allogeneic SCT. Molecular response was shown to be highly predictive for outcome and therefore constitutes a relevant study end point. The studies are registered at www.clinicaltrials.gov as NCT00199056 and NCT00198991. | ||
| 700 | 1 | |a Bartram, Claus R. |d 1952- |e VerfasserIn |0 (DE-588)139758518 |0 (DE-627)613089502 |0 (DE-576)312997159 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Blood |d Washington, DC : American Society of Hematology, 1946 |g 120(2012), 9, Seite 1868-1876 |h Online-Ressource |w (DE-627)266886647 |w (DE-600)1468538-3 |w (DE-576)075961938 |x 1528-0020 |7 nnas |a Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies |
| 773 | 1 | 8 | |g volume:120 |g year:2012 |g number:9 |g pages:1868-1876 |g extent:9 |a Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1182/blood-2011-09-377713 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.bloodjournal.org/content/120/9/1868 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181016 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 139758518 |a Bartram, Claus R. |m 139758518:Bartram, Claus R. |d 910000 |d 911500 |e 910000PB139758518 |e 911500PB139758518 |k 0/910000/ |k 1/910000/911500/ |p 5 | ||
| 999 | |a KXP-PPN1581946767 |e 3028872161 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["First Edition: March 22, 2012","Gesehen am 16.10.2018"],"relHost":[{"part":{"volume":"120","pages":"1868-1876","extent":"9","text":"120(2012), 9, Seite 1868-1876","year":"2012","issue":"9"},"note":["Gesehen am 21.04.2023"],"titleAlt":[{"title":"Blood online"}],"pubHistory":["1.1946 -"],"origin":[{"publisher":"American Society of Hematology ; Saunders ; HighWire Press","dateIssuedKey":"1946","dateIssuedDisp":"1946-","publisherPlace":"Washington, DC ; Philadelphia, Pa. ; Stanford, Calif."}],"id":{"eki":["266886647"],"zdb":["1468538-3"],"issn":["1528-0020"]},"recId":"266886647","disp":"Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapiesBlood","title":[{"title_sort":"Blood","title":"Blood","subtitle":"journal of the American Society of Hematology"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"corporate":[{"role":"isb","display":"American Society of Hematology"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"]}],"title":[{"title_sort":"Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies","title":"Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies"}],"person":[{"family":"Gökbuget","role":"aut","given":"Nicola","display":"Gökbuget, Nicola"},{"family":"Bartram","role":"aut","given":"Claus R.","display":"Bartram, Claus R."}],"physDesc":[{"extent":"9 S."}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"August 30, 2012","dateIssuedKey":"2012"}],"id":{"eki":["1581946767"],"doi":["10.1182/blood-2011-09-377713"]},"recId":"1581946767","name":{"displayForm":["Nicola Gökbuget, Michael Kneba, Thorsten Raff, Heiko Trautmann, Claus-Rainer Bartram, Renate Arnold, Rainer Fietkau, Mathias Freund, Arnold Ganser, Wolf-Dieter Ludwig, Georg Maschmeyer, Harald Rieder, Stefan Schwartz, Hubert Serve, Eckhard Thiel, Monika Brüggemann, and Dieter Hoelzer, on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia"]}} | ||
| SRT | |a GOEKBUGETNADULTPATIE3020 | ||