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Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy

Background Tumour-infiltrating lymphocytes (TILs) are predictive for response to neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) and HER2-positive breast cancer, but their role in luminal breast cancer and the effect of TILs on prognosis in all subtypes is less clear. Here, we asses...

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Hauptverfasser: Denkert, Carsten (VerfasserIn) , Schneeweiss, Andreas (VerfasserIn) , Sinn, Peter (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2018
In: The lancet. Oncology
Year: 2017, Jahrgang: 19, Heft: 1, Pages: 40-50
ISSN:1474-5488
DOI:10.1016/S1470-2045(17)30904-X
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/S1470-2045(17)30904-X
Verlag, Volltext: https://linkinghub.elsevier.com/retrieve/pii/S147020451730904X
Volltext
Verfasserangaben:Carsten Denkert, Gunter von Minckwitz, Silvia Darb-Esfahani, Bianca Lederer, Barbara I Heppner, Karsten E Weber, Jan Budczies, Jens Huober, Frederick Klauschen, Jenny Furlanetto, Wolfgang D Schmitt, Jens-Uwe Blohmer, Thomas Karn, Berit M Pfitzner, Sherko Kümmel, Knut Engels, Andreas Schneeweiss, Arndt Hartmann, Aurelia Noske, Peter A Fasching, Christian Jackisch, Marion van Mackelenbergh, Peter Sinn, Christian Schem, Claus Hanusch, Michael Untch, Sibylle Loibl
Beschreibung
Zusammenfassung:Background Tumour-infiltrating lymphocytes (TILs) are predictive for response to neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) and HER2-positive breast cancer, but their role in luminal breast cancer and the effect of TILs on prognosis in all subtypes is less clear. Here, we assessed the relevance of TILs for chemotherapy response and prognosis in patients with TNBC, HER2-positive breast cancer, and luminal-HER2-negative breast cancer.
Beschreibung:Published online December 7, 2017
Gesehen am 17.10.2018
Beschreibung:Online Resource
ISSN:1474-5488
DOI:10.1016/S1470-2045(17)30904-X

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