The incomplete glutathione puzzle: just guessing at numbers and figures?
Significance: Glutathione metabolism is comparable to a jigsaw puzzle with too many pieces. It is supposed to comprise (i) the reduction of disulfides, hydroperoxides, sulfenic acids, and nitrosothiols, (ii) the detoxification of aldehydes, xenobiotics, and heavy metals, and (iii) the synthesis of eico...
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
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20 Nov 2017
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| In: |
Antioxidants & redox signaling
Year: 2017, Jahrgang: 27, Heft: 15, Pages: 1130-1161 |
| ISSN: | 1557-7716 |
| DOI: | 10.1089/ars.2017.7123 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1089/ars.2017.7123 Verlag, Volltext: http://www.liebertpub.com/doi/10.1089/ars.2017.7123 
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| Verfasserangaben: | Marcel Deponte |
| Zusammenfassung: | Significance: Glutathione metabolism is comparable to a jigsaw puzzle with too many pieces. It is supposed to comprise (i) the reduction of disulfides, hydroperoxides, sulfenic acids, and nitrosothiols, (ii) the detoxification of aldehydes, xenobiotics, and heavy metals, and (iii) the synthesis of eicosanoids, steroids, and iron-sulfur clusters. In addition, glutathione affects oxidative protein folding and redox signaling. Here, I try to provide an overview on the relevance of glutathione-dependent pathways with an emphasis on quantitative data. |
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| Beschreibung: | Online ahead of editing: May 25, 2017 Gesehen am 17.10.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1557-7716 |
| DOI: | 10.1089/ars.2017.7123 |