Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test
Evidence exists that chronic antidepressant therapy enhances CREB levels and activity. Nevertheless, the data are not conclusive, as previous analysis of transgenic mouse models has suggested that CREB inactivation in fact contributes to antidepressant-like behavior. The aim of this study was to eva...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
18 October 2017
|
| In: |
Scientific reports
Year: 2017, Jahrgang: 7 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-14069-6 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41598-017-14069-6 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-017-14069-6 
|
| Verfasserangaben: | Katarzyna Rafa-Zabłocka, Grzegorz Kreiner, Monika Bagińska, Justyna Kuśmierczyk, Rosanna Parlato, & Irena Nalepa |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1582128081 | ||
| 003 | DE-627 | ||
| 005 | 20220815034247.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181019s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41598-017-14069-6 |2 doi | |
| 035 | |a (DE-627)1582128081 | ||
| 035 | |a (DE-576)512128081 | ||
| 035 | |a (DE-599)BSZ512128081 | ||
| 035 | |a (OCoLC)1341020106 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Rafa-Zabłocka, Katarzyna |e VerfasserIn |0 (DE-588)116945464X |0 (DE-627)1034157078 |0 (DE-576)512128200 |4 aut | |
| 245 | 1 | 0 | |a Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test |c Katarzyna Rafa-Zabłocka, Grzegorz Kreiner, Monika Bagińska, Justyna Kuśmierczyk, Rosanna Parlato, & Irena Nalepa |
| 264 | 1 | |c 18 October 2017 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 19.10.2018 | ||
| 520 | |a Evidence exists that chronic antidepressant therapy enhances CREB levels and activity. Nevertheless, the data are not conclusive, as previous analysis of transgenic mouse models has suggested that CREB inactivation in fact contributes to antidepressant-like behavior. The aim of this study was to evaluate the role of CREB in this context by exploiting novel transgenic mouse models, characterized by selective ablation of CREB restricted to noradrenergic (Creb1DBHCre/Crem−/−) or serotonergic (Creb1TPH2CreERT2/Crem−/−) neurons in a CREM-deficient background to avoid possible compensatory effects of CREM. Selective and functional ablation of CREB affected antidepressant-like behavior in a tail suspension test (TST) after antidepressant treatment. Contrary to single Creb1DBHCre mutants, Creb1DBHCre/Crem−/− mice did not respond to acute desipramine administration (20 mg/kg) on the TST. On the other hand, single Creb1TPH2CreERT2 mutants displayed reduced responses to fluoxetine (10 mg/kg) on the TST, while the effects in Creb1TPH2CreERT2/Crem−/− mice differed by gender. Our results provide further evidence for the important role of CREM as a compensatory factor. Additionally, the results indicate that new models based on the functional ablation of CREB in select neuronal populations may represent a valuable tool for investigating the role of CREB in the mechanism of antidepressant therapy. | ||
| 700 | 1 | |a Parlato, Rosanna |d 1973- |e VerfasserIn |0 (DE-588)1064026451 |0 (DE-627)812875338 |0 (DE-576)415235642 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scientific reports |d [London] : Springer Nature, 2011 |g 7(2017), Artikel-ID 13515 |h Online-Ressource |w (DE-627)663366712 |w (DE-600)2615211-3 |w (DE-576)346641179 |x 2045-2322 |7 nnas |a Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test |
| 773 | 1 | 8 | |g volume:7 |g year:2017 |g elocationid:13515 |g extent:11 |a Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41598-017-14069-6 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41598-017-14069-6 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181019 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1064026451 |a Parlato, Rosanna |m 1064026451:Parlato, Rosanna |p 5 |y j | ||
| 999 | |a KXP-PPN1582128081 |e 3029216438 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"recId":"663366712","disp":"Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension testScientific reports","origin":[{"publisher":"Springer Nature ; Nature Publishing Group","dateIssuedDisp":"2011-","dateIssuedKey":"2011","publisherPlace":"[London] ; London"}],"pubHistory":["1, article number 1 (2011)-"],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"note":["Gesehen am 12.07.24"],"id":{"zdb":["2615211-3"],"issn":["2045-2322"],"eki":["663366712"]},"part":{"text":"7(2017), Artikel-ID 13515","volume":"7","extent":"11","year":"2017"},"title":[{"title_sort":"Scientific reports","title":"Scientific reports"}]}],"person":[{"display":"Rafa-Zabłocka, Katarzyna","family":"Rafa-Zabłocka","role":"aut","given":"Katarzyna"},{"display":"Parlato, Rosanna","family":"Parlato","role":"aut","given":"Rosanna"}],"origin":[{"dateIssuedDisp":"18 October 2017","dateIssuedKey":"2017"}],"note":["Gesehen am 19.10.2018"],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test","title":"Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test"}],"physDesc":[{"extent":"11 S."}],"recId":"1582128081","name":{"displayForm":["Katarzyna Rafa-Zabłocka, Grzegorz Kreiner, Monika Bagińska, Justyna Kuśmierczyk, Rosanna Parlato, & Irena Nalepa"]},"id":{"eki":["1582128081"],"doi":["10.1038/s41598-017-14069-6"]}} | ||
| SRT | |a RAFAZABLOCTRANSGENIC1820 | ||