Assessing the impact of FoxP3 and Vav1 gene polymorphisms on kidney allograft survival
FoxP3 and Vav1 are known to be involved in the development of regulatory T cells. Two polymorphic sites in the FoxP3 promoter (rs3761548 and a (GT) n -dinucleotide repeat) and 2 single nucleotide polymorphisms in intron 1 of the Vav1 gene (rs2546133 and rs2617822) have been shown to correlate with g...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 2017
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| In: |
HLA
Year: 2017, Volume: 90, Issue: 2, Pages: 102-105 |
| ISSN: | 2059-2310 |
| DOI: | 10.1111/tan.13049 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1111/tan.13049 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tan.13049 
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| Author Notes: | M. Adamek, B. Döhler, K.K. Hasan, G. Fiedler, S. Scherer, G. Opelz, T.H. Tran |
| Summary: | FoxP3 and Vav1 are known to be involved in the development of regulatory T cells. Two polymorphic sites in the FoxP3 promoter (rs3761548 and a (GT) n -dinucleotide repeat) and 2 single nucleotide polymorphisms in intron 1 of the Vav1 gene (rs2546133 and rs2617822) have been shown to correlate with gene expression levels. We investigated a potential impact of FoxP3 and Vav1 genetic variants on kidney allograft failure using samples and data of the Collaborative Transplant Study. A cohort of 384 kidney transplant patients was tested. We found no significant association of FoxP3 promoter rs3761548 or (GT) n repeat length with presumed immunological graft failure. The genotype frequencies of Vav1 intron polymorphisms did not significantly differ between patients with graft failure and matched controls. |
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| Item Description: | First published: 03 May 2017 Gesehen am 22.10.2018 |
| Physical Description: | Online Resource |
| ISSN: | 2059-2310 |
| DOI: | 10.1111/tan.13049 |