Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis
Ding et al. characterize the function of the F-actin bundling protein plastin in the Caenorhabditis elegans zygote. They demonstrate that plastin is important for optimal connectivity in the cortical actomyosin network that drives large-scale contractile processes such as polarization and cytokinesi...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017 May 1
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| In: |
The journal of cell biology
Year: 2017, Volume: 216, Issue: 5, Pages: 1371-1386 |
| ISSN: | 1540-8140 |
| DOI: | 10.1083/jcb.201603070 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1083/jcb.201603070 Verlag, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412556/ 
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| Author Notes: | Wei Yung Ding, Hui Ting Ong, Yusuke Hara, Jantana Wongsantichon, Yusuke Toyama, Robert C. Robinson, François Nédélec, and Ronen Zaidel-Bar |
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| 520 | |a Ding et al. characterize the function of the F-actin bundling protein plastin in the Caenorhabditis elegans zygote. They demonstrate that plastin is important for optimal connectivity in the cortical actomyosin network that drives large-scale contractile processes such as polarization and cytokinesis., The cell cortex is essential to maintain animal cell shape, and contractile forces generated within it by nonmuscle myosin II (NMY-2) drive cellular morphogenetic processes such as cytokinesis. The role of actin cross-linking proteins in cortical dynamics is still incompletely understood. Here, we show that the evolutionarily conserved actin bundling/cross-linking protein plastin is instrumental for the generation of potent cortical actomyosin contractility in the Caenorhabditis elegans zygote. PLST-1 was enriched in contractile structures and was required for effective coalescence of NMY-2 filaments into large contractile foci and for long-range coordinated contractility in the cortex. In the absence of PLST-1, polarization was compromised, cytokinesis was delayed or failed, and 50% of embryos died during development. Moreover, mathematical modeling showed that an optimal amount of bundling agents enhanced the ability of a network to contract. We propose that by increasing the connectivity of the F-actin meshwork, plastin enables the cortex to generate stronger and more coordinated forces to accomplish cellular morphogenesis. | ||
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