MicroRNAs in cancer: small molecules, big chances
MicroRNAs have come to represent a significant mechanism of post transcriptional gene regulation affecting processes as varied as cellular differentiation, proliferation, metabolism, apoptosis, and cancer. As more miRNAs are unravelled and their roles dissected, it has become evident that the involv...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
|
| In: |
Anti-cancer agents in medicinal chemistry
Year: 2012, Jahrgang: 12, Heft: 7, Pages: 733-743 |
| ISSN: | 1875-5992 |
| DOI: | 10.2174/187152012802650273 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.2174/187152012802650273 Verlag, Volltext: http://www.eurekaselect.com.ezproxy.medma.uni-heidelberg.de/102220/article 
|
| Verfasserangaben: | Mohammed Abba, Giridhar Mudduluru and Heike Allgayer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1582152209 | ||
| 003 | DE-627 | ||
| 005 | 20230427193145.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181022s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2174/187152012802650273 |2 doi | |
| 035 | |a (DE-627)1582152209 | ||
| 035 | |a (DE-576)512152209 | ||
| 035 | |a (DE-599)BSZ512152209 | ||
| 035 | |a (OCoLC)1341020405 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Abba, Mohammed L. |d 1974- |e VerfasserIn |0 (DE-588)1024986101 |0 (DE-627)720854369 |0 (DE-576)369801407 |4 aut | |
| 245 | 1 | 0 | |a MicroRNAs in cancer |b small molecules, big chances |c Mohammed Abba, Giridhar Mudduluru and Heike Allgayer |
| 264 | 1 | |c 2012 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.10.2018 | ||
| 520 | |a MicroRNAs have come to represent a significant mechanism of post transcriptional gene regulation affecting processes as varied as cellular differentiation, proliferation, metabolism, apoptosis, and cancer. As more miRNAs are unravelled and their roles dissected, it has become evident that the involvement of these molecules in cancer is much more extensive than initially thought. Several miRNA expression analyses in both haematological malignancies and solid tumors have shown that, aside significant differences in expression between tumor and normal states, distinct tumor specific miRNA signatures exist. Additionally, the ability of miRNAs to mediate both oncogenic and tumor suppressor functions further broadens their functional significance. In recent years, efforts have intensified to utilize miRNAs therapeutically, especially in the context of oncomirs. As far as the impact and the success of this approach are concerned, it is still early days, but the potential is enormous. This review focuses on the important miRNAs that have been found to impact the tumorigenic process, how far we have come in terms of utilizing these molecules for therapy and the outlook for the near future. | ||
| 700 | 1 | |a Mudduluru, Giridhar |d 1974- |e VerfasserIn |0 (DE-588)141425938 |0 (DE-627)703976753 |0 (DE-576)323553397 |4 aut | |
| 700 | 1 | |a Allgayer, Heike |d 1969- |e VerfasserIn |0 (DE-588)1024987884 |0 (DE-627)720854466 |0 (DE-576)369805003 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Anti-cancer agents in medicinal chemistry |d Sharjah : Bentham Sc. Publ., 2006 |g 12(2012), 7, Seite 733-743 |h Online-Ressource |w (DE-627)518635597 |w (DE-600)2253831-8 |w (DE-576)273890913 |x 1875-5992 |7 nnas |a MicroRNAs in cancer small molecules, big chances |
| 773 | 1 | 8 | |g volume:12 |g year:2012 |g number:7 |g pages:733-743 |g extent:11 |a MicroRNAs in cancer small molecules, big chances |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2174/187152012802650273 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.eurekaselect.com.ezproxy.medma.uni-heidelberg.de/102220/article |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181022 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1024987884 |a Allgayer, Heike |m 1024987884:Allgayer, Heike |d 60000 |d 61800 |e 60000PA1024987884 |e 61800PA1024987884 |k 0/60000/ |k 1/60000/61800/ |p 3 |y j | ||
| 998 | |g 141425938 |a Mudduluru, Giridhar |m 141425938:Mudduluru, Giridhar |d 60000 |d 61800 |e 60000PM141425938 |e 61800PM141425938 |k 0/60000/ |k 1/60000/61800/ |p 2 | ||
| 998 | |g 1024986101 |a Abba, Mohammed L. |m 1024986101:Abba, Mohammed L. |d 60000 |d 61800 |e 60000PA1024986101 |e 61800PA1024986101 |k 0/60000/ |k 1/60000/61800/ |p 1 |x j | ||
| 999 | |a KXP-PPN1582152209 |e 3029377504 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"pubHistory":["6.2006 -"],"recId":"518635597","physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["518635597"],"issn":["1875-5992"],"zdb":["2253831-8"]},"disp":"MicroRNAs in cancer small molecules, big chancesAnti-cancer agents in medicinal chemistry","language":["eng"],"origin":[{"dateIssuedDisp":"2006-","publisherPlace":"Sharjah","dateIssuedKey":"2006","publisher":"Bentham Sc. Publ."}],"note":["Gesehen am 12.04.24"],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"Anti-cancer agents in medicinal chemistry","title_sort":"Anti-cancer agents in medicinal chemistry"}],"part":{"text":"12(2012), 7, Seite 733-743","pages":"733-743","year":"2012","volume":"12","extent":"11","issue":"7"}}],"id":{"eki":["1582152209"],"doi":["10.2174/187152012802650273"]},"name":{"displayForm":["Mohammed Abba, Giridhar Mudduluru and Heike Allgayer"]},"physDesc":[{"extent":"11 S."}],"recId":"1582152209","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 22.10.2018"],"origin":[{"dateIssuedDisp":"2012","dateIssuedKey":"2012"}],"title":[{"subtitle":"small molecules, big chances","title_sort":"MicroRNAs in cancer","title":"MicroRNAs in cancer"}],"language":["eng"],"person":[{"given":"Mohammed L.","role":"aut","family":"Abba","display":"Abba, Mohammed L."},{"role":"aut","given":"Giridhar","display":"Mudduluru, Giridhar","family":"Mudduluru"},{"family":"Allgayer","display":"Allgayer, Heike","role":"aut","given":"Heike"}]} | ||
| SRT | |a ABBAMOHAMMMICRORNASI2012 | ||