Magnetic resonance neurography visualizes abnormalities in sciatic and tibial nerves in patients with Type 1 diabetes and neuropathy
This study evaluates whether diffusion tensor imaging magnetic resonance neurography (DTI-MRN), T2 relaxation time, and proton spin density can detect and grade neuropathic abnormalities in patients with type 1 diabetes. Patients with type 1 diabetes (n = 49) were included—11 with severe polyneuropa...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
|
| In: |
Diabetes
Year: 2017, Jahrgang: 66, Heft: 7, Pages: 1779-1788 |
| ISSN: | 1939-327X |
| DOI: | 10.2337/db16-1049 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.2337/db16-1049 Verlag, Volltext: http://diabetes.diabetesjournals.org/content/66/7/1779 
|
| Verfasserangaben: | Michael Vaeggemose, Mirko Pham, Steffen Ringgaard, Hatice Tankisi, Niels Ejskjaer, Sabine Heiland, Per L. Poulsen, and Henning Andersen |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1582161178 | ||
| 003 | DE-627 | ||
| 005 | 20220815035004.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181022s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2337/db16-1049 |2 doi | |
| 035 | |a (DE-627)1582161178 | ||
| 035 | |a (DE-576)512161178 | ||
| 035 | |a (DE-599)BSZ512161178 | ||
| 035 | |a (OCoLC)1341020352 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Vaeggemose, Michael |e VerfasserIn |0 (DE-588)116961437X |0 (DE-627)1034715852 |0 (DE-576)512162689 |4 aut | |
| 245 | 1 | 0 | |a Magnetic resonance neurography visualizes abnormalities in sciatic and tibial nerves in patients with Type 1 diabetes and neuropathy |c Michael Vaeggemose, Mirko Pham, Steffen Ringgaard, Hatice Tankisi, Niels Ejskjaer, Sabine Heiland, Per L. Poulsen, and Henning Andersen |
| 264 | 1 | |c 2017 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.10.2018 | ||
| 520 | |a This study evaluates whether diffusion tensor imaging magnetic resonance neurography (DTI-MRN), T2 relaxation time, and proton spin density can detect and grade neuropathic abnormalities in patients with type 1 diabetes. Patients with type 1 diabetes (n = 49) were included—11 with severe polyneuropathy (sDPN), 13 with mild polyneuropathy (mDPN), and 25 without polyneuropathy (nDPN)—along with 30 healthy control subjects (HCs). Clinical examinations, nerve conduction studies, and vibratory perception thresholds determined the presence and severity of DPN. DTI-MRN covered proximal (sciatic nerve) and distal (tibial nerve) nerve segments of the lower extremity. Fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) were calculated, as were T2 relaxation time and proton spin density obtained from DTI-MRN. All magnetic resonance findings were related to the presence and severity of neuropathy. FA of the sciatic and tibial nerves was lowest in the sDPN group. Corresponding with this, proximal and distal ADCs were highest in patients with sDPN compared with patients with mDPN and nDPN, as well as the HCs. DTI-MRN correlated closely with the severity of neuropathy, demonstrating strong associations with sciatic and tibial nerve findings. Quantitative group differences in proton spin density were also significant, but less pronounced than those for DTI-MRN. In conclusion, DTI-MRN enables detection in peripheral nerves of abnormalities related to DPN, more so than proton spin density or T2 relaxation time. These abnormalities are likely to reflect pathology in sciatic and tibial nerve fibers. | ||
| 700 | 1 | |a Heiland, Sabine |e VerfasserIn |0 (DE-588)106732626X |0 (DE-627)818624450 |0 (DE-576)426561368 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Diabetes |d Alexandria, Va : Assoc., 1952 |g 66(2017), 7, Seite 1779-1788 |h Online-Ressource |w (DE-627)30671521X |w (DE-600)1501252-9 |w (DE-576)082437432 |x 1939-327X |7 nnas |a Magnetic resonance neurography visualizes abnormalities in sciatic and tibial nerves in patients with Type 1 diabetes and neuropathy |
| 773 | 1 | 8 | |g volume:66 |g year:2017 |g number:7 |g pages:1779-1788 |g extent:10 |a Magnetic resonance neurography visualizes abnormalities in sciatic and tibial nerves in patients with Type 1 diabetes and neuropathy |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2337/db16-1049 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://diabetes.diabetesjournals.org/content/66/7/1779 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181022 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 106732626X |a Heiland, Sabine |m 106732626X:Heiland, Sabine |d 910000 |d 911100 |e 910000PH106732626X |e 911100PH106732626X |k 0/910000/ |k 1/910000/911100/ |p 6 | ||
| 999 | |a KXP-PPN1582161178 |e 3029446778 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1582161178"],"doi":["10.2337/db16-1049"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Michael Vaeggemose, Mirko Pham, Steffen Ringgaard, Hatice Tankisi, Niels Ejskjaer, Sabine Heiland, Per L. Poulsen, and Henning Andersen"]},"language":["eng"],"recId":"1582161178","physDesc":[{"extent":"10 S."}],"title":[{"title":"Magnetic resonance neurography visualizes abnormalities in sciatic and tibial nerves in patients with Type 1 diabetes and neuropathy","title_sort":"Magnetic resonance neurography visualizes abnormalities in sciatic and tibial nerves in patients with Type 1 diabetes and neuropathy"}],"person":[{"family":"Vaeggemose","given":"Michael","role":"aut","display":"Vaeggemose, Michael"},{"family":"Heiland","given":"Sabine","display":"Heiland, Sabine","role":"aut"}],"relHost":[{"disp":"Magnetic resonance neurography visualizes abnormalities in sciatic and tibial nerves in patients with Type 1 diabetes and neuropathyDiabetes","language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"subtitle":"a journal of the American Diabetes Association","title_sort":"Diabetes","title":"Diabetes"}],"part":{"pages":"1779-1788","text":"66(2017), 7, Seite 1779-1788","issue":"7","volume":"66","year":"2017","extent":"10"},"corporate":[{"display":"American Diabetes Association","role":"isb"}],"recId":"30671521X","pubHistory":["1.1952 -"],"id":{"eki":["30671521X"],"issn":["1939-327X"],"zdb":["1501252-9"]},"note":["Gesehen am 21.01.2022"],"origin":[{"dateIssuedKey":"1952","publisherPlace":"Alexandria, Va","dateIssuedDisp":"1952-","publisher":"Assoc."}],"physDesc":[{"extent":"Online-Ressource"}]}],"origin":[{"dateIssuedDisp":"2017","dateIssuedKey":"2017"}],"note":["Gesehen am 22.10.2018"]} | ||
| SRT | |a VAEGGEMOSEMAGNETICRE2017 | ||