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Joint effects of the epigenetic alteration of neurotrophins and cytokine signaling: a possible exploratory model of affective symptoms in alcohol-dependent patients?

Methods: In this study we investigated a possible association between alterations in the methylation of the BDNF IV/NGF I gene promoter and the cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in 55 male alcohol-dependent patients. Results: Mean methylation of the promoter of the B...

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Main Authors: Heberlein, Annemarie (Author) , Schuster, Rilana (Author)
Format: Article (Journal)
Language:English
Published: 25 January 2017
In: Alcohol and alcoholism
Year: 2017, Volume: 52, Issue: 3, Pages: 277-281
ISSN:1464-3502
DOI:10.1093/alcalc/agw100
Online Access:Verlag, Volltext: http://dx.doi.org/10.1093/alcalc/agw100
Verlag, Volltext: https://academic.oup.com/alcalc/article-lookup/doi/10.1093/alcalc/agw100
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Author Notes:Annemarie Heberlein, Rilana Schuster, Alexandra Kleimann, Adrian Groh, Andreas Kordon, Birgitt Opfermann, Ralf Lichtinghagen, Michael Gröschl, Johannes Kornhuber, Stefan Bleich, Helge Frieling, and Thomas Hillemacher
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Summary:Methods: In this study we investigated a possible association between alterations in the methylation of the BDNF IV/NGF I gene promoter and the cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in 55 male alcohol-dependent patients. Results: Mean methylation of the promoter of the BDNF gene was significantly associated with the TNF-α serum levels and the CIWA-score during withdrawal (P < 0.001). Moreover, mean methylation of the NGF I promoter was significantly associated with the IL-6 serum levels and STAI-I score during withdrawal (P < 0.001). Conclusion: Our results suggest an association between the epigenetic regulation of both neurotrophins, BDNF and NGF, cytokine release and the symptomatology of alcohol dependence. They imply that changes in the methylation of neurotrophins may contribute to the symptomatology of alcohol dependence by affecting relevant downstream signaling cascades.
Item Description:Gesehen am 22.10.2018
Physical Description:Online Resource
ISSN:1464-3502
DOI:10.1093/alcalc/agw100

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