Connexin 36 promotes cortical spreading depolarization and ischemic brain damage
Cortical spreading depolarization (CSD) promotes the progression of neuronal injury after cerebral ischemia. However, the mechanisms of propagation of postischemic CSD events are still unclear. In this study we characterized the role of the main neuronal gap junction protein connexin 36 (Cx36) in ge...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 October 2012
|
| In: |
Brain research
Year: 2012, Volume: 1479, Pages: 80-85 |
| ISSN: | 1872-6240 |
| DOI: | 10.1016/j.brainres.2012.08.046 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.brainres.2012.08.046 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0006899312014205 
|
| Author Notes: | Panagiotis Bargiotas, Sajjad Muhammad, Mahbubur Rahman, Nurith Jakob, Raimund Trabold, Elke Fuchs, Lothar Schilling, Nikolaus Plesnila, Hannah Monyer, Markus Schwaninger |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1582184127 | ||
| 003 | DE-627 | ||
| 005 | 20230427193150.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181023s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.brainres.2012.08.046 |2 doi | |
| 035 | |a (DE-627)1582184127 | ||
| 035 | |a (DE-576)512184127 | ||
| 035 | |a (DE-599)BSZ512184127 | ||
| 035 | |a (OCoLC)1341020474 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bargiotas, Panagiotis |d 1981- |e VerfasserIn |0 (DE-588)1028373899 |0 (DE-627)730621898 |0 (DE-576)375908234 |4 aut | |
| 245 | 1 | 0 | |a Connexin 36 promotes cortical spreading depolarization and ischemic brain damage |c Panagiotis Bargiotas, Sajjad Muhammad, Mahbubur Rahman, Nurith Jakob, Raimund Trabold, Elke Fuchs, Lothar Schilling, Nikolaus Plesnila, Hannah Monyer, Markus Schwaninger |
| 264 | 1 | |c 15 October 2012 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 31 August 2012 | ||
| 500 | |a Gesehen am 23.10.2018 | ||
| 520 | |a Cortical spreading depolarization (CSD) promotes the progression of neuronal injury after cerebral ischemia. However, the mechanisms of propagation of postischemic CSD events are still unclear. In this study we characterized the role of the main neuronal gap junction protein connexin 36 (Cx36) in generating postischemic CSDs. In Cx36-deficient mice and controls we occluded the distal middle cerebral artery. To detect CSD events we recorded the direct current and laser Doppler flow. In addition, locomotor function and the infarct size were determined. Cx36-deficient mice had significantly fewer and shorter CSD events than wild-type controls. Additionally, Cx36 deletion is neuroprotective, leading to a better functional outcome and decreased infarct size after ischemia. These results suggest a detrimental role for Cx36 after ischemia, possibly by promoting CSD. | ||
| 650 | 4 | |a Cortical spreading depression | |
| 650 | 4 | |a Electrical synapse | |
| 650 | 4 | |a Ischemia | |
| 650 | 4 | |a MCAO | |
| 650 | 4 | |a Neuroprotection | |
| 700 | 1 | |a Muḥammad, Sajjad |d 1978- |e VerfasserIn |0 (DE-588)13781500X |0 (DE-627)596129823 |0 (DE-576)304644471 |4 aut | |
| 700 | 1 | |a Rahman, Mahbubur |e VerfasserIn |0 (DE-588)1030059519 |0 (DE-627)734645090 |0 (DE-576)377877891 |4 aut | |
| 700 | 1 | |a Jakob, Nurith Juliane |d 1975- |e VerfasserIn |0 (DE-588)124928331 |0 (DE-627)368365328 |0 (DE-576)186692757 |4 aut | |
| 700 | 1 | |a Fuchs, Elke C. |e VerfasserIn |0 (DE-588)1156391350 |0 (DE-627)1019232668 |0 (DE-576)18585253X |4 aut | |
| 700 | 1 | |a Schilling, Lothar |d 1954- |e VerfasserIn |0 (DE-588)1028374690 |0 (DE-627)730623521 |0 (DE-576)375909893 |4 aut | |
| 700 | 1 | |a Monyer, Hannah |d 1957- |e VerfasserIn |0 (DE-588)1012792374 |0 (DE-627)662740416 |0 (DE-576)345945514 |4 aut | |
| 700 | 1 | |a Schwaninger, Markus |e VerfasserIn |0 (DE-588)1028374909 |0 (DE-627)730623939 |0 (DE-576)375910174 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Brain research |d Amsterdam : Elsevier, 1966 |g 1479(2012), Seite 80-85 |h Online-Ressource |w (DE-627)254635776 |w (DE-600)1462674-3 |w (DE-576)074530976 |x 1872-6240 |7 nnas |a Connexin 36 promotes cortical spreading depolarization and ischemic brain damage |
| 773 | 1 | 8 | |g volume:1479 |g year:2012 |g pages:80-85 |g extent:6 |a Connexin 36 promotes cortical spreading depolarization and ischemic brain damage |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |t Connexin 36 promotes cortical spreading depolarization and ischemic brain damage |d 2012 |w (DE-627)1445908387 |w (DE-576)375908382 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.brainres.2012.08.046 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0006899312014205 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181023 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1028374909 |a Schwaninger, Markus |m 1028374909:Schwaninger, Markus |d 50000 |e 50000PS1028374909 |k 0/50000/ |p 10 |y j | ||
| 998 | |g 1012792374 |a Monyer, Hannah |m 1012792374:Monyer, Hannah |d 910000 |d 911100 |e 910000PM1012792374 |e 911100PM1012792374 |k 0/910000/ |k 1/910000/911100/ |p 9 | ||
| 998 | |g 1028374690 |a Schilling, Lothar |m 1028374690:Schilling, Lothar |d 60000 |d 62600 |e 60000PS1028374690 |e 62600PS1028374690 |k 0/60000/ |k 1/60000/62600/ |p 7 | ||
| 998 | |g 1156391350 |a Fuchs, Elke C. |m 1156391350:Fuchs, Elke C. |d 700000 |d 712000 |d 712100 |e 700000PF1156391350 |e 712000PF1156391350 |e 712100PF1156391350 |k 0/700000/ |k 1/700000/712000/ |k 2/700000/712000/712100/ |p 6 | ||
| 998 | |g 124928331 |a Jakob, Nurith Juliane |m 124928331:Jakob, Nurith Juliane |d 910000 |d 911100 |e 910000PJ124928331 |e 911100PJ124928331 |k 0/910000/ |k 1/910000/911100/ |p 4 | ||
| 998 | |g 1030059519 |a Rahman, Mahbubur |m 1030059519:Rahman, Mahbubur |d 50000 |d 54600 |e 50000PR1030059519 |e 54600PR1030059519 |k 0/50000/ |k 1/50000/54600/ |p 3 | ||
| 998 | |g 13781500X |a Muḥammad, Sajjad |m 13781500X:Muḥammad, Sajjad |d 50000 |d 54600 |e 50000PM13781500X |e 54600PM13781500X |k 0/50000/ |k 1/50000/54600/ |p 2 | ||
| 998 | |g 1028373899 |a Bargiotas, Panagiotis |m 1028373899:Bargiotas, Panagiotis |d 50000 |d 54600 |e 50000PB1028373899 |e 54600PB1028373899 |k 0/50000/ |k 1/50000/54600/ |p 1 |x j | ||
| 999 | |a KXP-PPN1582184127 |e 3029479978 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Panagiotis Bargiotas, Sajjad Muhammad, Mahbubur Rahman, Nurith Jakob, Raimund Trabold, Elke Fuchs, Lothar Schilling, Nikolaus Plesnila, Hannah Monyer, Markus Schwaninger"]},"recId":"1582184127","note":["Available online 31 August 2012","Gesehen am 23.10.2018"],"person":[{"family":"Bargiotas","display":"Bargiotas, Panagiotis","given":"Panagiotis","role":"aut"},{"given":"Sajjad","display":"Muḥammad, Sajjad","family":"Muḥammad","role":"aut"},{"role":"aut","given":"Mahbubur","display":"Rahman, Mahbubur","family":"Rahman"},{"given":"Nurith Juliane","family":"Jakob","display":"Jakob, Nurith Juliane","role":"aut"},{"role":"aut","display":"Fuchs, Elke C.","family":"Fuchs","given":"Elke C."},{"given":"Lothar","family":"Schilling","display":"Schilling, Lothar","role":"aut"},{"family":"Monyer","display":"Monyer, Hannah","given":"Hannah","role":"aut"},{"given":"Markus","display":"Schwaninger, Markus","family":"Schwaninger","role":"aut"}],"title":[{"title_sort":"Connexin 36 promotes cortical spreading depolarization and ischemic brain damage","title":"Connexin 36 promotes cortical spreading depolarization and ischemic brain damage"}],"physDesc":[{"extent":"6 S."}],"relHost":[{"titleAlt":[{"title":"Brain research interactive"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Brain research","title":"Brain research","subtitle":"an international multidisciplinary journal devoted to fundamental research in the brain sciences"}],"part":{"extent":"6","year":"2012","volume":"1479","text":"1479(2012), Seite 80-85","pages":"80-85"},"language":["eng"],"id":{"eki":["254635776"],"zdb":["1462674-3"],"issn":["1872-6240"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"publisher":"Elsevier","dateIssuedKey":"1966","publisherPlace":"Amsterdam","dateIssuedDisp":"1966-"}],"name":{"displayForm":["ed. board K. Akert [u.a.]"]},"note":["Gesehen am 22.01.2020"],"pubHistory":["1.1966 -"],"recId":"254635776","disp":"Connexin 36 promotes cortical spreading depolarization and ischemic brain damageBrain research"}],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"15 October 2012"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1016/j.brainres.2012.08.046"],"eki":["1582184127"]},"language":["eng"]} | ||
| SRT | |a BARGIOTASPCONNEXIN361520 | ||