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Connexin 36 promotes cortical spreading depolarization and ischemic brain damage

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Cortical spreading depolarization (CSD) promotes the progression of neuronal injury after cerebral ischemia. However, the mechanisms of propagation of postischemic CSD events are still unclear. In this study we characterized the role of the main neuronal gap junction protein connexin 36 (Cx36) in ge...

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Main Authors: Bargiotas, Panagiotis (Author) , Muḥammad, Sajjad (Author) , Rahman, Mahbubur (Author) , Jakob, Nurith Juliane (Author) , Fuchs, Elke C. (Author) , Schilling, Lothar (Author) , Monyer, Hannah (Author) , Schwaninger, Markus (Author)
Format: Article (Journal)
Language:English
Published: 15 October 2012
In: Brain research
Year: 2012, Volume: 1479, Pages: 80-85
ISSN:1872-6240
DOI:10.1016/j.brainres.2012.08.046
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.brainres.2012.08.046
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0006899312014205
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Author Notes:Panagiotis Bargiotas, Sajjad Muhammad, Mahbubur Rahman, Nurith Jakob, Raimund Trabold, Elke Fuchs, Lothar Schilling, Nikolaus Plesnila, Hannah Monyer, Markus Schwaninger
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Summary:Cortical spreading depolarization (CSD) promotes the progression of neuronal injury after cerebral ischemia. However, the mechanisms of propagation of postischemic CSD events are still unclear. In this study we characterized the role of the main neuronal gap junction protein connexin 36 (Cx36) in generating postischemic CSDs. In Cx36-deficient mice and controls we occluded the distal middle cerebral artery. To detect CSD events we recorded the direct current and laser Doppler flow. In addition, locomotor function and the infarct size were determined. Cx36-deficient mice had significantly fewer and shorter CSD events than wild-type controls. Additionally, Cx36 deletion is neuroprotective, leading to a better functional outcome and decreased infarct size after ischemia. These results suggest a detrimental role for Cx36 after ischemia, possibly by promoting CSD.
Item Description:Available online 31 August 2012
Gesehen am 23.10.2018
Physical Description:Online Resource
ISSN:1872-6240
DOI:10.1016/j.brainres.2012.08.046

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