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Coagulation testing in acute ischemic stroke patients taking non–vitamin k antagonist oral anticoagulants

Background and Purpose—In patients who present with acute ischemic stroke while on treatment with non-vitamin K antagonist oral anticoagulants (NOACs), coagulation testing is necessary to confirm the eligibility for thrombolytic therapy. We evaluated the current use of coagulation testing in routine...

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Bibliographische Detailangaben
Hauptverfasser: Purrucker, Jan (VerfasserIn) , Rizos, Timolaos (VerfasserIn) , Khan, Shujah (VerfasserIn) , Veltkamp, Roland (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2017
In: Stroke
Year: 2016, Jahrgang: 48, Heft: 1, Pages: 152-158
ISSN:1524-4628
DOI:10.1161/STROKEAHA.116.014963
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1161/STROKEAHA.116.014963
Verlag, Volltext: https://www.ahajournals.org/doi/10.1161/STROKEAHA.116.014963
Volltext
Verfasserangaben:Jan C. Purrucker, Kirsten Haas, Timolaos Rizos, Shujah Khan, Sven Poli, Peter Kraft, Christoph Kleinschnitz, Rainer Dziewas, Andreas Binder, Frederick Palm, Sebastian Jander, Hassan Soda, Peter U. Heuschmann, Roland Veltkamp, for the RASUNOA Investigators (Registry of Acute Stroke Under New Oral Anticoagulants) ...
Beschreibung
Zusammenfassung:Background and Purpose—In patients who present with acute ischemic stroke while on treatment with non-vitamin K antagonist oral anticoagulants (NOACs), coagulation testing is necessary to confirm the eligibility for thrombolytic therapy. We evaluated the current use of coagulation testing in routine clinical practice in patients who were on NOAC treatment at the time of acute ischemic stroke. Methods—Prospective multicenter observational RASUNOA registry (Registry of Acute Stroke Under New Oral Anticoagulants; February 2012-2015). Results of locally performed nonspecific (international normalized ratio, activated partial thromboplastin time, and thrombin time) and specific (antifactor Xa tests, hemoclot assay) coagulation tests were documented. The implications of test results for thrombolysis decision-making were explored. Results—In the 290 patients enrolled, nonspecific coagulation tests were performed in ≥95% and specific coagulation tests in 26.9% of patients.
Beschreibung:Originally published 29 Nov 2016
Gesehen am 23.10.2018
Beschreibung:Online Resource
ISSN:1524-4628
DOI:10.1161/STROKEAHA.116.014963

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