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Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling

The mechanistic link between metabolic stress and associated cardiomyopathy is unknown. Here the authors show that high fat diet causes calpain-1-dependent degradation of ERK5 leading to mitochondrial dysfunction, suggesting the maintenance of cardiac ERK5 as a therapeutic approach for cardiomyopath...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Wei (VerfasserIn) , Jungmann, Andreas (VerfasserIn) , Müller, Oliver J. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 08 September 2017
In: Nature Communications
Year: 2017, Jahrgang: 8
ISSN:2041-1723
DOI:10.1038/s41467-017-00664-8
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41467-017-00664-8
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-017-00664-8
Volltext
Verfasserangaben:Wei Liu, Andrea Ruiz-Velasco, Shoubao Wang, Saba Khan, Min Zi, Andreas Jungmann, Maria Dolores Camacho-Muñoz, Jing Guo, Guanhua Du, Liping Xie, Delvac Oceandy, Anna Nicolaou, Gina Galli, Oliver J. Müller, Elizabeth J. Cartwright, Yong Ji & Xin Wang
Beschreibung
Zusammenfassung:The mechanistic link between metabolic stress and associated cardiomyopathy is unknown. Here the authors show that high fat diet causes calpain-1-dependent degradation of ERK5 leading to mitochondrial dysfunction, suggesting the maintenance of cardiac ERK5 as a therapeutic approach for cardiomyopathy prevention and/or treatment.
Beschreibung:Gesehen am 23.10.2018
Beschreibung:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-017-00664-8

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