Galectin-3 inhibits the chemotaxis of human polymorphonuclear neutrophils in vitro
In the recent years, the participation of the animal lectin galectin (gal)-3 in inflammation and in host defence mechanisms was extensively studied. In vivo studies implied – among others – a role of gal-3 in the recruitment of polymorphonuclear neutrophils (PMN) to sites of bacterial infection. In...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
|
| In: |
Immunobiology
Year: 2012, Volume: 217, Issue: 1, Pages: 83-90 |
| ISSN: | 1878-3279 |
| DOI: | 10.1016/j.imbio.2011.07.031 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.imbio.2011.07.031 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0171298511001720 
|
| Author Notes: | Billur Baseras, Matthias M. Gaida, Nadine Kahle, Ann-Kathrin Schuppel, Diana Kathrey, Birgit Prior, Moritz Wente, Gertrud Maria Hänsch |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1582236739 | ||
| 003 | DE-627 | ||
| 005 | 20230427193155.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181024s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.imbio.2011.07.031 |2 doi | |
| 035 | |a (DE-627)1582236739 | ||
| 035 | |a (DE-576)512236739 | ||
| 035 | |a (DE-599)BSZ512236739 | ||
| 035 | |a (OCoLC)1341021322 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Baseras, Billur |d 1986- |e VerfasserIn |0 (DE-588)102732844X |0 (DE-627)728901358 |0 (DE-576)372857841 |4 aut | |
| 245 | 1 | 0 | |a Galectin-3 inhibits the chemotaxis of human polymorphonuclear neutrophils in vitro |c Billur Baseras, Matthias M. Gaida, Nadine Kahle, Ann-Kathrin Schuppel, Diana Kathrey, Birgit Prior, Moritz Wente, Gertrud Maria Hänsch |
| 264 | 1 | |c 2012 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 5 August 2011 | ||
| 500 | |a Gesehen am 24.10.2018 | ||
| 520 | |a In the recent years, the participation of the animal lectin galectin (gal)-3 in inflammation and in host defence mechanisms was extensively studied. In vivo studies implied – among others – a role of gal-3 in the recruitment of polymorphonuclear neutrophils (PMN) to sites of bacterial infection. In that context, we asked the question whether gal-3 was chemotactic for PMN. Functional assays revealed that gal-3 was not chemotactic for PMN, but that it inhibited the spontaneous migration and the chemotaxis of PMN towards complement C5a, interleukin (IL)-8, or ATP. Moreover, gal-3 inhibited the shape change and the actin polymerisation of PMN that occurs in response to C5a or IL-8. By use of FITC-labelled gal-3, we found that it attached rapidly to the PMN membrane in a lactose-sensitive manner. In response to gal-3 the MAP kinase p38 was phosphorylated. This kinase is crucial for the migration of PMN towards end-target chemokines, such as C5a, and is activated in response to C5a or IL-8. When PMN were preincubated with gal-3, the C5a-induced p38 phosphorylation was transiently enhanced, but eventually down-modulated. We conclude that by interfering with the chemokine-induced p38 phosphorylation gal-3 inhibits chemotaxis of PMN. | ||
| 700 | 1 | |a Gaida, Matthias |d 1982- |e VerfasserIn |0 (DE-588)139102620 |0 (DE-627)703207377 |0 (DE-576)309804523 |4 aut | |
| 700 | 1 | |a Kahle, Nadine |d 1982- |e VerfasserIn |0 (DE-588)1038440335 |0 (DE-627)757414990 |0 (DE-576)392402637 |4 aut | |
| 700 | 1 | |a Schuppel, Ann-Kathrin |e VerfasserIn |0 (DE-588)1169778046 |0 (DE-627)1035882973 |0 (DE-576)512241686 |4 aut | |
| 700 | 1 | |a Kathrey, Diana |e VerfasserIn |0 (DE-588)116977881X |0 (DE-627)1035883872 |0 (DE-576)512242143 |4 aut | |
| 700 | 1 | |a Prior, Birgit |e VerfasserIn |0 (DE-588)1078649200 |0 (DE-627)839016107 |0 (DE-576)451587154 |4 aut | |
| 700 | 1 | |a Wente, Moritz N. |d 1973- |e VerfasserIn |0 (DE-588)123201829 |0 (DE-627)082409161 |0 (DE-576)293602549 |4 aut | |
| 700 | 1 | |a Hänsch, Gertrud Maria |e VerfasserIn |0 (DE-588)1032383380 |0 (DE-627)738394076 |0 (DE-576)323810926 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Immunobiology |d München : Elsevier, 1979 |g 217(2012), 1, Seite 83-90 |h Online-Ressource |w (DE-627)335415989 |w (DE-600)2060227-3 |w (DE-576)096290919 |x 1878-3279 |7 nnas |a Galectin-3 inhibits the chemotaxis of human polymorphonuclear neutrophils in vitro |
| 773 | 1 | 8 | |g volume:217 |g year:2012 |g number:1 |g pages:83-90 |g extent:8 |a Galectin-3 inhibits the chemotaxis of human polymorphonuclear neutrophils in vitro |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.imbio.2011.07.031 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0171298511001720 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181024 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1032383380 |a Hänsch, Gertrud Maria |m 1032383380:Hänsch, Gertrud Maria |d 910000 |d 911600 |e 910000PH1032383380 |e 911600PH1032383380 |k 0/910000/ |k 1/910000/911600/ |p 8 |y j | ||
| 998 | |g 123201829 |a Wente, Moritz N. |m 123201829:Wente, Moritz N. |d 50000 |e 50000PW123201829 |k 0/50000/ |p 7 | ||
| 998 | |g 1078649200 |a Prior, Birgit |m 1078649200:Prior, Birgit |d 910000 |d 911600 |e 910000PP1078649200 |e 911600PP1078649200 |k 0/910000/ |k 1/910000/911600/ |p 6 | ||
| 998 | |g 116977881X |a Kathrey, Diana |m 116977881X:Kathrey, Diana |d 910000 |d 911600 |e 910000PK116977881X |e 911600PK116977881X |k 0/910000/ |k 1/910000/911600/ |p 5 | ||
| 998 | |g 1169778046 |a Schuppel, Ann-Kathrin |m 1169778046:Schuppel, Ann-Kathrin |d 910000 |d 911600 |e 910000PS1169778046 |e 911600PS1169778046 |k 0/910000/ |k 1/910000/911600/ |p 4 | ||
| 998 | |g 1038440335 |a Kahle, Nadine |m 1038440335:Kahle, Nadine |d 910000 |d 911600 |e 910000PK1038440335 |e 911600PK1038440335 |k 0/910000/ |k 1/910000/911600/ |p 3 | ||
| 998 | |g 139102620 |a Gaida, Matthias |m 139102620:Gaida, Matthias |d 910000 |d 912000 |e 910000PG139102620 |e 912000PG139102620 |k 0/910000/ |k 1/910000/912000/ |p 2 | ||
| 998 | |g 102732844X |a Baseras, Billur |m 102732844X:Baseras, Billur |d 910000 |d 911600 |e 910000PB102732844X |e 911600PB102732844X |k 0/910000/ |k 1/910000/911600/ |p 1 |x j | ||
| 999 | |a KXP-PPN1582236739 |e 3029612074 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"physDesc":[{"extent":"8 S."}],"id":{"doi":["10.1016/j.imbio.2011.07.031"],"eki":["1582236739"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Billur Baseras, Matthias M. Gaida, Nadine Kahle, Ann-Kathrin Schuppel, Diana Kathrey, Birgit Prior, Moritz Wente, Gertrud Maria Hänsch"]},"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"2012"}],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["156.1979/80,4 -"],"origin":[{"publisher":"Elsevier ; Urban & Fischer","dateIssuedKey":"1979","dateIssuedDisp":"1979-","publisherPlace":"München ; Jena"}],"recId":"335415989","title":[{"title_sort":"Immunobiology","subtitle":"experimental and clinical","title":"Immunobiology"}],"note":["Gesehen am 12.02.20"],"part":{"extent":"8","volume":"217","pages":"83-90","year":"2012","text":"217(2012), 1, Seite 83-90","issue":"1"},"disp":"Galectin-3 inhibits the chemotaxis of human polymorphonuclear neutrophils in vitroImmunobiology","physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"id":{"issn":["1878-3279"],"eki":["335415989"],"zdb":["2060227-3"]}}],"person":[{"family":"Baseras","display":"Baseras, Billur","given":"Billur","role":"aut"},{"display":"Gaida, Matthias","given":"Matthias","role":"aut","family":"Gaida"},{"family":"Kahle","role":"aut","given":"Nadine","display":"Kahle, Nadine"},{"family":"Schuppel","role":"aut","given":"Ann-Kathrin","display":"Schuppel, Ann-Kathrin"},{"family":"Kathrey","display":"Kathrey, Diana","given":"Diana","role":"aut"},{"role":"aut","given":"Birgit","display":"Prior, Birgit","family":"Prior"},{"display":"Wente, Moritz N.","given":"Moritz N.","role":"aut","family":"Wente"},{"role":"aut","given":"Gertrud Maria","display":"Hänsch, Gertrud Maria","family":"Hänsch"}],"recId":"1582236739","title":[{"title_sort":"Galectin-3 inhibits the chemotaxis of human polymorphonuclear neutrophils in vitro","title":"Galectin-3 inhibits the chemotaxis of human polymorphonuclear neutrophils in vitro"}],"note":["Available online 5 August 2011","Gesehen am 24.10.2018"]} | ||
| SRT | |a BASERASBILGALECTIN3I2012 | ||