Fetal and postnatal metal dysregulation in autism
Genetic and environmental factors contribute to the etiologies of autism spectrum disorder (ASD), but evidence of specific environmental exposures and susceptibility windows is limited. Here we study monozygotic and dizygotic twins discordant for ASD to test whether fetal and postnatal metal dysregu...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 Jun 2017
|
| In: |
Nature Communications
Year: 2017, Jahrgang: 8 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms15493 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1038/ncomms15493 Verlag, Volltext: https://www.nature.com/articles/ncomms15493 
|
| Verfasserangaben: | Manish Arora, Abraham Reichenberg, Charlotte Willfors, Christine Austin, Chris Gennings, Steve Berggren, Paul Lichtenstein, Henrik Anckarsäter, Kristiina Tammimies, Sven Bölte |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1582310211 | ||
| 003 | DE-627 | ||
| 005 | 20220815041702.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181025s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/ncomms15493 |2 doi | |
| 035 | |a (DE-627)1582310211 | ||
| 035 | |a (DE-576)512310211 | ||
| 035 | |a (DE-599)BSZ512310211 | ||
| 035 | |a (OCoLC)1341021788 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Arora, Manish |e VerfasserIn |0 (DE-588)1169877974 |0 (DE-627)1036474798 |0 (DE-576)512310157 |4 aut | |
| 245 | 1 | 0 | |a Fetal and postnatal metal dysregulation in autism |c Manish Arora, Abraham Reichenberg, Charlotte Willfors, Christine Austin, Chris Gennings, Steve Berggren, Paul Lichtenstein, Henrik Anckarsäter, Kristiina Tammimies, Sven Bölte |
| 264 | 1 | |c 1 Jun 2017 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.10.2018 | ||
| 520 | |a Genetic and environmental factors contribute to the etiologies of autism spectrum disorder (ASD), but evidence of specific environmental exposures and susceptibility windows is limited. Here we study monozygotic and dizygotic twins discordant for ASD to test whether fetal and postnatal metal dysregulation increases ASD risk. Using validated tooth-matrix biomarkers, we estimate pre- and post-natal exposure profiles of essential and toxic elements. Significant divergences are apparent in metal uptake between ASD cases and their control siblings, but only during discrete developmental periods. Cases have reduced uptake of essential elements manganese and zinc, and higher uptake of the neurotoxin lead. Manganese and lead are also correlated with ASD severity and autistic traits. Our study suggests that metal toxicant uptake and essential element deficiency during specific developmental windows increases ASD risk and severity, supporting the hypothesis of systemic elemental dysregulation in ASD. Independent replication in population-based studies is needed to extend these findings. | ||
| 700 | 1 | |a Bölte, Sven |d 1968- |e VerfasserIn |0 (DE-588)122572068 |0 (DE-627)082024898 |0 (DE-576)183781708 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature Communications |d [London] : Springer Nature, 2010 |g 8(2017), Artikel-ID 15493 |h Online-Ressource |w (DE-627)626457688 |w (DE-600)2553671-0 |w (DE-576)331555905 |x 2041-1723 |7 nnas |a Fetal and postnatal metal dysregulation in autism |
| 773 | 1 | 8 | |g volume:8 |g year:2017 |g elocationid:15493 |g extent:10 |a Fetal and postnatal metal dysregulation in autism |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/ncomms15493 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/ncomms15493 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181025 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 122572068 |a Bölte, Sven |m 122572068:Bölte, Sven |d 60000 |e 60000PB122572068 |k 0/60000/ |p 10 |y j | ||
| 999 | |a KXP-PPN1582310211 |e 3029718433 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"disp":"Fetal and postnatal metal dysregulation in autismNature Communications","note":["Gesehen am 13.06.24"],"origin":[{"dateIssuedDisp":"[2010]-","publisherPlace":"[London] ; [London]","publisher":"Springer Nature ; Nature Publishing Group UK"}],"title":[{"title_sort":"Nature Communications","title":"Nature Communications"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"extent":"10","volume":"8","year":"2017","text":"8(2017), Artikel-ID 15493"},"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["2010-"],"recId":"626457688","id":{"issn":["2041-1723"],"eki":["626457688"],"zdb":["2553671-0"]}}],"id":{"eki":["1582310211"],"doi":["10.1038/ncomms15493"]},"name":{"displayForm":["Manish Arora, Abraham Reichenberg, Charlotte Willfors, Christine Austin, Chris Gennings, Steve Berggren, Paul Lichtenstein, Henrik Anckarsäter, Kristiina Tammimies, Sven Bölte"]},"physDesc":[{"extent":"10 S."}],"recId":"1582310211","note":["Gesehen am 25.10.2018"],"origin":[{"dateIssuedDisp":"1 Jun 2017","dateIssuedKey":"2017"}],"title":[{"title":"Fetal and postnatal metal dysregulation in autism","title_sort":"Fetal and postnatal metal dysregulation in autism"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"person":[{"display":"Arora, Manish","family":"Arora","given":"Manish","role":"aut"},{"display":"Bölte, Sven","family":"Bölte","given":"Sven","role":"aut"}]} | ||
| SRT | |a ARORAMANISFETALANDPO1201 | ||