Circulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetes
Fibronectin is ubiquitously expressed in the extracellular matrix, and its accumulation in the glomerular mesangium in diabetic nephropathy is associated with deterioration of renal function in these patients. However, the exact role of fibronectin in the pathogenesis of diabetic nephropathy remains...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 2017
|
| In: |
Kidney international
Year: 2017, Jahrgang: 91, Heft: 6, Pages: 1374-1385 |
| ISSN: | 1523-1755 |
| DOI: | 10.1016/j.kint.2016.12.006 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.kint.2016.12.006 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0085253816307062 
|
| Verfasserangaben: | Verena Klemis, Hiba Ghura, Giuseppina Federico, Carina Würfel, Anke Bentmann, Norbert Gretz, Tatsuhiko Miyazaki, Hermann-Joseph Gröne, Inaam A. Nakchbandi |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1582367000 | ||
| 003 | DE-627 | ||
| 005 | 20240316100536.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181029s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.kint.2016.12.006 |2 doi | |
| 035 | |a (DE-627)1582367000 | ||
| 035 | |a (DE-576)512367000 | ||
| 035 | |a (DE-599)BSZ512367000 | ||
| 035 | |a (OCoLC)1341020491 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Klemis, Verena |e VerfasserIn |0 (DE-588)1162547847 |0 (DE-627)102668143X |0 (DE-576)507490231 |4 aut | |
| 245 | 1 | 0 | |a Circulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetes |c Verena Klemis, Hiba Ghura, Giuseppina Federico, Carina Würfel, Anke Bentmann, Norbert Gretz, Tatsuhiko Miyazaki, Hermann-Joseph Gröne, Inaam A. Nakchbandi |
| 264 | 1 | |c June 2017 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.10.2018 | ||
| 520 | |a Fibronectin is ubiquitously expressed in the extracellular matrix, and its accumulation in the glomerular mesangium in diabetic nephropathy is associated with deterioration of renal function in these patients. However, the exact role of fibronectin in the pathogenesis of diabetic nephropathy remains unknown. To clarify this, we administered fluorescent-labeled plasma fibronectin to wild-type mice and found it to accumulate in the mesangium. Using liver-specific conditional-knockout mice to decrease circulating fibronectin, we reduced circulating fibronectin by more than 90%. In streptozotocin-induced diabetes of these knockout mice, the pronounced fall in circulating fibronectin resulted in a decrease in mesangial expansion by 25% and a decline in albuminuria by 30% compared to diabetic control mice. Indeed, the amount of fibronectin in the kidney was reduced, as was the total amount of collagen. In vitro experiments confirmed that matrix accumulation of fibronectin was enhanced by increasing fibronectin only, glucose only, or the combination of both. Thus, circulating fibronectin contributes to mesangial expansion and exacerbation of albuminuria in a murine model of type 1 diabetes. | ||
| 650 | 4 | |a circulation | |
| 650 | 4 | |a diabetes mellitus | |
| 650 | 4 | |a fibronectin | |
| 650 | 4 | |a mesangial expansion | |
| 650 | 4 | |a nephropathy | |
| 700 | 1 | |a Ghura, Hiba |d 1987- |e VerfasserIn |0 (DE-588)1156675065 |0 (DE-627)1019505745 |0 (DE-576)502359196 |4 aut | |
| 700 | 1 | |a Federico, Giuseppina |d 1985- |e VerfasserIn |0 (DE-588)1074440315 |0 (DE-627)832196770 |0 (DE-576)442691963 |4 aut | |
| 700 | 1 | |a Bentmann, Anke |d 1980- |e VerfasserIn |0 (DE-588)136424473 |0 (DE-627)583281915 |0 (DE-576)30101275X |4 aut | |
| 700 | 1 | |a Gretz, Norbert |d 1954-2023 |e VerfasserIn |0 (DE-588)1020104589 |0 (DE-627)691105154 |0 (DE-576)359544843 |4 aut | |
| 700 | 1 | |a Gröne, Hermann-Josef |d 1950- |e VerfasserIn |0 (DE-588)1054822697 |0 (DE-627)792339541 |0 (DE-576)170213773 |4 aut | |
| 700 | 1 | |a Nakchbandi, Inaam |d 1967- |e VerfasserIn |0 (DE-588)142756881 |0 (DE-627)638931053 |0 (DE-576)188363874 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Kidney international |d New York, NY : Elsevier, 1972 |g 91(2017), 6, Seite 1374-1385 |h Online-Ressource |w (DE-627)32046637X |w (DE-600)2007940-0 |w (DE-576)091143004 |x 1523-1755 |7 nnas |a Circulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetes |
| 773 | 1 | 8 | |g volume:91 |g year:2017 |g number:6 |g pages:1374-1385 |g extent:12 |a Circulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetes |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.kint.2016.12.006 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0085253816307062 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181029 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1054822697 |a Gröne, Hermann-Josef |m 1054822697:Gröne, Hermann-Josef |d 50000 |e 50000PG1054822697 |k 0/50000/ |p 8 | ||
| 998 | |g 1074440315 |a Federico, Giuseppina |m 1074440315:Federico, Giuseppina |d 910000 |e 910000PF1074440315 |k 0/910000/ |p 3 | ||
| 998 | |g 142756881 |a Nakchbandi, Inaam |m 142756881:Nakchbandi, Inaam |d 910000 |d 911600 |e 910000PN142756881 |e 911600PN142756881 |k 0/910000/ |k 1/910000/911600/ |p 9 |y j | ||
| 998 | |g 1020104589 |a Gretz, Norbert |m 1020104589:Gretz, Norbert |d 60000 |d 999811 |e 60000PG1020104589 |e 999811PG1020104589 |k 0/60000/ |k 1/60000/999811/ |p 6 | ||
| 998 | |g 136424473 |a Bentmann, Anke |m 136424473:Bentmann, Anke |d 910000 |d 911600 |e 910000PB136424473 |e 911600PB136424473 |k 0/910000/ |k 1/910000/911600/ |p 5 | ||
| 998 | |g 1156675065 |a Ghura, Hiba |m 1156675065:Ghura, Hiba |d 910000 |d 911600 |e 910000PG1156675065 |e 911600PG1156675065 |k 0/910000/ |k 1/910000/911600/ |p 2 | ||
| 998 | |g 1162547847 |a Klemis, Verena |m 1162547847:Klemis, Verena |d 910000 |d 911600 |e 910000PK1162547847 |e 911600PK1162547847 |k 0/910000/ |k 1/910000/911600/ |p 1 |x j | ||
| 999 | |a KXP-PPN1582367000 |e 3029944581 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title":"Circulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetes","title_sort":"Circulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetes"}],"name":{"displayForm":["Verena Klemis, Hiba Ghura, Giuseppina Federico, Carina Würfel, Anke Bentmann, Norbert Gretz, Tatsuhiko Miyazaki, Hermann-Joseph Gröne, Inaam A. Nakchbandi"]},"id":{"doi":["10.1016/j.kint.2016.12.006"],"eki":["1582367000"]},"origin":[{"dateIssuedDisp":"June 2017","dateIssuedKey":"2017"}],"relHost":[{"language":["eng"],"corporate":[{"display":"International Society of Nephrology","role":"isb","roleDisplay":"Herausgebendes Organ"}],"recId":"32046637X","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 20.08.20"],"disp":"Circulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetesKidney international","type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"extent":"12","year":"2017","issue":"6","text":"91(2017), 6, Seite 1374-1385","pages":"1374-1385","volume":"91"},"origin":[{"dateIssuedKey":"1972","publisher":"Elsevier ; Blackwell ; Wiley-Blackwell ; Nature Publishing Group","publisherPlace":"New York, NY ; Oxford [u.a.] ; [Erscheinungsort nicht ermittelbar] ; Basingstoke","dateIssuedDisp":"1972-"}],"id":{"zdb":["2007940-0"],"issn":["1523-1755"],"eki":["32046637X"]},"title":[{"title_sort":"Kidney international","title":"Kidney international","subtitle":"official journal of the International Society of Nephrology"}],"pubHistory":["1.1972 -"]}],"physDesc":[{"extent":"12 S."}],"language":["eng"],"recId":"1582367000","note":["Gesehen am 29.10.2018"],"person":[{"roleDisplay":"VerfasserIn","role":"aut","display":"Klemis, Verena","given":"Verena","family":"Klemis"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Ghura, Hiba","family":"Ghura","given":"Hiba"},{"family":"Federico","given":"Giuseppina","roleDisplay":"VerfasserIn","role":"aut","display":"Federico, Giuseppina"},{"display":"Bentmann, Anke","roleDisplay":"VerfasserIn","role":"aut","family":"Bentmann","given":"Anke"},{"family":"Gretz","given":"Norbert","display":"Gretz, Norbert","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Hermann-Josef","family":"Gröne","display":"Gröne, Hermann-Josef","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Nakchbandi","given":"Inaam","display":"Nakchbandi, Inaam","role":"aut","roleDisplay":"VerfasserIn"}]} | ||
| SRT | |a KLEMISVERECIRCULATIN2017 | ||