Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival
Myelin, made by oligodendrocytes, is essential for rapid information transfer in the central nervous system. Oligodendrocyte precursors (OPs) receive glutamatergic synaptic input from axons but how this affects their development is unclear. Murine OPs in white matter express AMPA receptor (AMPAR) su...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 June 2017
|
| In: |
eLife
Year: 2017, Jahrgang: 6 |
| ISSN: | 2050-084X |
| DOI: | 10.7554/eLife.28080 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.7554/eLife.28080 Verlag, Volltext: https://doi.org/10.7554/eLife.28080 
|
| Verfasserangaben: | Eleni Kougioumtzidou, Takahiro Shimizu, Nicola B Hamilton, Koujiro Tohyama, Rolf Sprengel, Hannah Monyer, David Attwell, William D Richardson |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1582423636 | ||
| 003 | DE-627 | ||
| 005 | 20220815043157.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181030s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.7554/eLife.28080 |2 doi | |
| 035 | |a (DE-627)1582423636 | ||
| 035 | |a (DE-576)512423636 | ||
| 035 | |a (DE-599)BSZ512423636 | ||
| 035 | |a (OCoLC)1341020492 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kougioumtzidou, Eleni |e VerfasserIn |0 (DE-588)1170186823 |0 (DE-627)1037620879 |0 (DE-576)512423407 |4 aut | |
| 245 | 1 | 0 | |a Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival |c Eleni Kougioumtzidou, Takahiro Shimizu, Nicola B Hamilton, Koujiro Tohyama, Rolf Sprengel, Hannah Monyer, David Attwell, William D Richardson |
| 264 | 1 | |c 13 June 2017 | |
| 300 | |a 31 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 30.10.2018 | ||
| 520 | |a Myelin, made by oligodendrocytes, is essential for rapid information transfer in the central nervous system. Oligodendrocyte precursors (OPs) receive glutamatergic synaptic input from axons but how this affects their development is unclear. Murine OPs in white matter express AMPA receptor (AMPAR) subunits GluA2, GluA3 and GluA4. We generated mice in which OPs lack both GluA2 and GluA3, or all three subunits GluA2/3/4, which respectively reduced or abolished AMPAR-mediated input to OPs. In both double- and triple-knockouts OP proliferation and number were unchanged but ~25% fewer oligodendrocytes survived in the subcortical white matter during development. In triple knockouts, this shortfall persisted into adulthood. The oligodendrocyte deficit resulted in ~20% fewer myelin sheaths but the average length, number and thickness of myelin internodes made by individual oligodendrocytes appeared normal. Thus, AMPAR-mediated signalling from active axons stimulates myelin production in developing white matter by enhancing oligodendrocyte survival, without influencing myelin synthesis per se. | ||
| 650 | 4 | |a survival | |
| 650 | 4 | |a AMPA receptor | |
| 650 | 4 | |a conditional knockout | |
| 650 | 4 | |a glutamate | |
| 650 | 4 | |a internode length | |
| 650 | 4 | |a oligodendrocyte | |
| 700 | 1 | |a Sprengel, Rolf |d 1955- |e VerfasserIn |0 (DE-588)1060395665 |0 (DE-627)799661228 |0 (DE-576)163694230 |4 aut | |
| 700 | 1 | |a Monyer, Hannah |d 1957- |e VerfasserIn |0 (DE-588)1012792374 |0 (DE-627)662740416 |0 (DE-576)345945514 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t eLife |d Cambridge : eLife Sciences Publications, 2012 |g 6(2017), Artikel-ID e28080 |h Online-Ressource |w (DE-627)728518384 |w (DE-600)2687154-3 |w (DE-576)372567576 |x 2050-084X |7 nnas |a Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival |
| 773 | 1 | 8 | |g volume:6 |g year:2017 |g elocationid:e28080 |g extent:31 |a Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival |
| 856 | 4 | 0 | |u http://dx.doi.org/10.7554/eLife.28080 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.7554/eLife.28080 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181030 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1012792374 |a Monyer, Hannah |m 1012792374:Monyer, Hannah |d 910000 |d 911100 |e 910000PM1012792374 |e 911100PM1012792374 |k 0/910000/ |k 1/910000/911100/ |p 6 | ||
| 998 | |g 1060395665 |a Sprengel, Rolf |m 1060395665:Sprengel, Rolf |p 5 | ||
| 999 | |a KXP-PPN1582423636 |e 3030082601 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 30.10.2018"],"recId":"1582423636","name":{"displayForm":["Eleni Kougioumtzidou, Takahiro Shimizu, Nicola B Hamilton, Koujiro Tohyama, Rolf Sprengel, Hannah Monyer, David Attwell, William D Richardson"]},"relHost":[{"disp":"Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survivaleLife","note":["Gesehen am 28.06.17"],"pubHistory":["1.2012 -"],"recId":"728518384","language":["eng"],"id":{"eki":["728518384"],"zdb":["2687154-3"],"issn":["2050-084X"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2012","publisher":"eLife Sciences Publications","publisherPlace":"Cambridge","dateIssuedDisp":"2012-"}],"title":[{"title_sort":"eLife","title":"eLife"}],"titleAlt":[{"title":"eLife journal"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"text":"6(2017), Artikel-ID e28080","volume":"6","year":"2017","extent":"31"}}],"person":[{"role":"aut","given":"Eleni","family":"Kougioumtzidou","display":"Kougioumtzidou, Eleni"},{"role":"aut","family":"Sprengel","display":"Sprengel, Rolf","given":"Rolf"},{"display":"Monyer, Hannah","family":"Monyer","given":"Hannah","role":"aut"}],"physDesc":[{"extent":"31 S."}],"title":[{"title":"Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival","title_sort":"Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival"}],"origin":[{"dateIssuedDisp":"13 June 2017","dateIssuedKey":"2017"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.7554/eLife.28080"],"eki":["1582423636"]},"language":["eng"]} | ||
| SRT | |a KOUGIOUMTZSIGNALLING1320 | ||