Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1
The Notch1-mediated signaling pathway has a central role in the maintenance of neural stem cells and contributes to growth and progression of glioblastomas, the most frequent malignant brain tumors in adults. Here, we demonstrate that the Notch1 receptor promotes survival of glioblastoma cells by re...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 November 2012
|
| In: |
Oncogene
Year: 2012, Volume: 31, Issue: 44, Pages: 4698-4708 |
| ISSN: | 1476-5594 |
| DOI: | 10.1038/onc.2011.615 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/onc.2011.615
|
| Author Notes: | A. Fassl, K.E. Tagscherer, J. Richter, M. Berriel Diaz, S.R. Alcantara Llaguno, B. Campos, J. Kopitz, C. Herold-Mende, S. Herzig, M.H.H. Schmidt, L.F. Parada, O.D. Wiestler and W. Roth |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1582425485 | ||
| 003 | DE-627 | ||
| 005 | 20230427193217.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181030s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/onc.2011.615 |2 doi | |
| 035 | |a (DE-627)1582425485 | ||
| 035 | |a (DE-576)512425485 | ||
| 035 | |a (DE-599)BSZ512425485 | ||
| 035 | |a (OCoLC)1341022036 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Faßl, Anne |e VerfasserIn |0 (DE-588)1029853371 |0 (DE-627)734362900 |0 (DE-576)37769942X |4 aut | |
| 245 | 1 | 0 | |a Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1 |c A. Fassl, K.E. Tagscherer, J. Richter, M. Berriel Diaz, S.R. Alcantara Llaguno, B. Campos, J. Kopitz, C. Herold-Mende, S. Herzig, M.H.H. Schmidt, L.F. Parada, O.D. Wiestler and W. Roth |
| 264 | 1 | |c 01 November 2012 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 30.10.2018 | ||
| 520 | |a The Notch1-mediated signaling pathway has a central role in the maintenance of neural stem cells and contributes to growth and progression of glioblastomas, the most frequent malignant brain tumors in adults. Here, we demonstrate that the Notch1 receptor promotes survival of glioblastoma cells by regulation of the anti-apoptotic Mcl-1 protein. Notch1-dependent regulation of Mcl-1 occurs cell type dependent at a transcriptional or post-translational level and is mediated by the induction of epidermal growth factor receptor (EGFR). Inhibition of the Notch1 pathway overcomes apoptosis resistance and sensitizes glioblastoma cells to apoptosis induced by ionizing radiation, the death ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) or the Bcl-2/Bcl-XL inhibitor ABT-737. In conclusion, targeting Notch1 might represent a promising novel strategy in the treatment of glioblastomas. | ||
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Cell Line, Tumor | |
| 650 | 4 | |a Cell Proliferation | |
| 650 | 4 | |a Cell Survival | |
| 650 | 4 | |a Drug Resistance, Neoplasm | |
| 650 | 4 | |a Gene Expression Regulation, Neoplastic | |
| 650 | 4 | |a Gene Silencing | |
| 650 | 4 | |a Glioblastoma | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Myeloid Cell Leukemia Sequence 1 Protein | |
| 650 | 4 | |a Proto-Oncogene Proteins c-bcl-2 | |
| 650 | 4 | |a Proto-Oncogene Proteins c-raf | |
| 650 | 4 | |a Receptor, Epidermal Growth Factor | |
| 650 | 4 | |a Receptor, Notch1 | |
| 650 | 4 | |a RNA Processing, Post-Transcriptional | |
| 650 | 4 | |a Signal Transduction | |
| 650 | 4 | |a Transcription, Genetic | |
| 700 | 1 | |a Tagscherer, Katrin |e VerfasserIn |0 (DE-588)138997543 |0 (DE-627)703175580 |0 (DE-576)309386039 |4 aut | |
| 700 | 1 | |a Berriel Diaz, Mauricio |d 1971- |e VerfasserIn |0 (DE-588)1124103996 |0 (DE-627)877827648 |0 (DE-576)482304693 |4 aut | |
| 700 | 1 | |a Campos, Benito |d 1980- |e VerfasserIn |0 (DE-588)142071943 |0 (DE-627)704135280 |0 (DE-576)327466723 |4 aut | |
| 700 | 1 | |a Kopitz, Jürgen |e VerfasserIn |0 (DE-588)1033923397 |0 (DE-627)743674472 |0 (DE-576)16530393X |4 aut | |
| 700 | 1 | |a Herold-Mende, Christel |e VerfasserIn |0 (DE-588)1022936549 |0 (DE-627)717335577 |0 (DE-576)366194267 |4 aut | |
| 700 | 1 | |a Herzig, Stephan |d 1969- |e VerfasserIn |0 (DE-588)12146623X |0 (DE-627)705470857 |0 (DE-576)292725949 |4 aut | |
| 700 | 1 | |a Roth, Wilfried |d 1970- |e VerfasserIn |0 (DE-588)120891557 |0 (DE-627)080951279 |0 (DE-576)292433484 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Oncogene |d London : Springer Nature, 1997 |g 31(2012), 44, Seite 4698-4708 |h Online-Ressource |w (DE-627)320469964 |w (DE-600)2008404-3 |w (DE-576)096188715 |x 1476-5594 |7 nnas |a Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1 |
| 773 | 1 | 8 | |g volume:31 |g year:2012 |g number:44 |g pages:4698-4708 |g extent:11 |a Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/onc.2011.615 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181030 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 120891557 |a Roth, Wilfried |m 120891557:Roth, Wilfried |d 910000 |d 912000 |e 910000PR120891557 |e 912000PR120891557 |k 0/910000/ |k 1/910000/912000/ |p 13 |y j | ||
| 998 | |g 12146623X |a Herzig, Stephan |m 12146623X:Herzig, Stephan |d 50000 |e 50000PH12146623X |k 0/50000/ |p 9 | ||
| 998 | |g 1022936549 |a Herold-Mende, Christel |m 1022936549:Herold-Mende, Christel |d 910000 |d 911100 |e 910000PH1022936549 |e 911100PH1022936549 |k 0/910000/ |k 1/910000/911100/ |p 8 | ||
| 998 | |g 1033923397 |a Kopitz, Jürgen |m 1033923397:Kopitz, Jürgen |d 910000 |d 912000 |e 910000PK1033923397 |e 912000PK1033923397 |k 0/910000/ |k 1/910000/912000/ |p 7 | ||
| 998 | |g 142071943 |a Campos, Benito |m 142071943:Campos, Benito |d 910000 |d 911200 |e 910000PC142071943 |e 911200PC142071943 |k 0/910000/ |k 1/910000/911200/ |p 6 | ||
| 998 | |g 1124103996 |a Berriel Diaz, Mauricio |m 1124103996:Berriel Diaz, Mauricio |d 140000 |e 140000PB1124103996 |k 0/140000/ |p 4 | ||
| 998 | |g 138997543 |a Tagscherer, Katrin |m 138997543:Tagscherer, Katrin |p 2 | ||
| 998 | |g 1029853371 |a Faßl, Anne |m 1029853371:Faßl, Anne |p 1 |x j | ||
| 999 | |a KXP-PPN1582425485 |e 3030085058 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"11 S."}],"person":[{"given":"Anne","family":"Faßl","roleDisplay":"VerfasserIn","display":"Faßl, Anne","role":"aut"},{"role":"aut","display":"Tagscherer, Katrin","roleDisplay":"VerfasserIn","family":"Tagscherer","given":"Katrin"},{"given":"Mauricio","family":"Berriel Diaz","roleDisplay":"VerfasserIn","display":"Berriel Diaz, Mauricio","role":"aut"},{"roleDisplay":"VerfasserIn","given":"Benito","family":"Campos","role":"aut","display":"Campos, Benito"},{"roleDisplay":"VerfasserIn","family":"Kopitz","given":"Jürgen","role":"aut","display":"Kopitz, Jürgen"},{"role":"aut","display":"Herold-Mende, Christel","roleDisplay":"VerfasserIn","given":"Christel","family":"Herold-Mende"},{"role":"aut","display":"Herzig, Stephan","roleDisplay":"VerfasserIn","family":"Herzig","given":"Stephan"},{"family":"Roth","given":"Wilfried","roleDisplay":"VerfasserIn","display":"Roth, Wilfried","role":"aut"}],"title":[{"title_sort":"Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1","title":"Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1"}],"recId":"1582425485","relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"zdb":["2008404-3"],"eki":["320469964"],"issn":["1476-5594"]},"part":{"text":"31(2012), 44, Seite 4698-4708","volume":"31","year":"2012","pages":"4698-4708","issue":"44","extent":"11"},"note":["Gesehen am 18.03.05"],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1Oncogene","title":[{"title_sort":"Oncogene","title":"Oncogene","subtitle":"including Oncogene reviews"}],"pubHistory":["Nachgewiesen 14.1997 -"],"recId":"320469964","language":["eng"],"origin":[{"publisher":"Springer Nature ; Nature Publ. Group","publisherPlace":"London ; Basingstoke","dateIssuedKey":"1997","dateIssuedDisp":"1997-"}]}],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"01 November 2012"}],"language":["eng"],"id":{"doi":["10.1038/onc.2011.615"],"eki":["1582425485"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 30.10.2018"],"name":{"displayForm":["A. Fassl, K.E. Tagscherer, J. Richter, M. Berriel Diaz, S.R. Alcantara Llaguno, B. Campos, J. Kopitz, C. Herold-Mende, S. Herzig, M.H.H. Schmidt, L.F. Parada, O.D. Wiestler and W. Roth"]}} | ||
| SRT | |a FASSLANNETNOTCH1SIGN0120 | ||