Left ventricular diastolic function in type 2 diabetes mellitus is associated with myocardial triglyceride content but not with impaired myocardial perfusion reserve
Purpose: To study myocardial perfusion reserve and myocellular metabolic alterations indicated by triglyceride content as possible causes of diastolic dysfunction in patients with type 2 diabetes mellitus, preserved systolic function, and without clinically evident coronary artery disease. Materials...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 26, 2012
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| In: |
Journal of magnetic resonance imaging
Year: 2012, Jahrgang: 35, Heft: 4, Pages: 804-811 |
| ISSN: | 1522-2586 |
| DOI: | 10.1002/jmri.22879 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1002/jmri.22879 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.22879 
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| Verfasserangaben: | Grigorios Korosoglou, Per M. Humpert, Johannes Ahrens, Dimitrios Oikonomou, Nael F. Osman, Gitsios Gitsioudis, Sebastian J. Buss, Henning Steen, Bernhardt Schnackenburg, Angelika Bierhaus, Peter P. Nawroth, and Hugo A. Katus |
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| 245 | 1 | 0 | |a Left ventricular diastolic function in type 2 diabetes mellitus is associated with myocardial triglyceride content but not with impaired myocardial perfusion reserve |c Grigorios Korosoglou, Per M. Humpert, Johannes Ahrens, Dimitrios Oikonomou, Nael F. Osman, Gitsios Gitsioudis, Sebastian J. Buss, Henning Steen, Bernhardt Schnackenburg, Angelika Bierhaus, Peter P. Nawroth, and Hugo A. Katus |
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| 500 | |a First published: 08 November 2011 | ||
| 500 | |a Gesehen am 30.10.2018 | ||
| 520 | |a Purpose: To study myocardial perfusion reserve and myocellular metabolic alterations indicated by triglyceride content as possible causes of diastolic dysfunction in patients with type 2 diabetes mellitus, preserved systolic function, and without clinically evident coronary artery disease. Materials and Methods: Patients with type 2 diabetes mellitus (n = 42) underwent cardiac magnetic resonance (CMR) for quantification of 1) myocardial contractility by strain-encoded MR (SENC); 2) myocardial triglyceride content by proton magnetic resonance spectroscopy (1H-MRS); and 3) myocardial perfusion reserve during pharmacologic hyperemia. Age-matched healthy volunteers (n = 16) also underwent CMR to acquire normal values for myocardial strain and perfusion reserve. Results: Stress CMR procedures were successfully performed in all subjects, and no regional inducible perfusion defects were observed in type 2 diabetes mellitus patients. Diastolic strain rate and myocardial perfusion reserve were significantly impaired in patients with type 2 diabetes mellitus compared to control subjects (P < 0.001 for both). Interestingly, impaired diastolic function in type 2 diabetes mellitus was not associated with impaired myocardial perfusion reserve (r = 0.12, P = NS). Conversely a significant association was observed between diastolic dysfunction and myocardial triglyceride content (r = −0.71, P < 0.001), which proved to be independent of age, gender, diabetes duration, blood pressure, and fasting blood glucose. Conclusion: Myocardial steatosis may represent an early marker of diabetic heart disease, triggering subclinical myocardial dysfunction irrespective of myocardial perfusion reserve. J. Magn. Reson. Imaging 2012;35:804-811. | ||
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