Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility
Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant associa...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 2012
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| In: |
Schizophrenia research
Year: 2012, Jahrgang: 142, Heft: 1/3, Pages: 200-205 |
| ISSN: | 1573-2509 |
| DOI: | 10.1016/j.schres.2012.10.008 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.schres.2012.10.008 Verlag, Volltext: https://www.sciencedirect.com/science/article/pii/S0920996412005804 
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| Verfasserangaben: | Ming Li, Yi Wang, Xue-bin Zheng, Masashi Ikeda, Nakao Iwata, Xiong-jian Luo, Siow-Ann Chong, Jimmy Lee, Marcella Rietschel, Fengyu Zhang, Bertram Müller-Myhsok, Sven Cichon, Daniel R.Weinberger, Manuel Mattheisen, Thomas G. Schulze, Nicholas G. Martin, Philip B. Mitchell, Peter R. Schofield, Jian-jun Liu, Bing Su and MooDS Consortium |
| Zusammenfassung: | Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P = 3.17 × 10− 4, N = 7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia. |
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| Beschreibung: | Gesehen am 30.10.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1573-2509 |
| DOI: | 10.1016/j.schres.2012.10.008 |