Alterations of leptin in the course of inflammation and severe sepsis
The adipokine leptin regulates energy expenditure, vascular function, bone and cartilage growth as well as the immune system and systemic inflammatory response. Several activating effects towards T cells, monocytes, endothelium cells and cytokine production have been reported suggesting a protective...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 September 2012
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| In: |
BMC infectious diseases
Year: 2012, Jahrgang: 12, Pages: 1-10 |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/1471-2334-12-217 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1186/1471-2334-12-217
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| Verfasserangaben: | Michael Behnes, Martina Brueckmann, Siegfried Lang, Christian Putensen, Joachim Saur, Martin Borggrefe and Ursula Hoffmann |
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| 520 | |a The adipokine leptin regulates energy expenditure, vascular function, bone and cartilage growth as well as the immune system and systemic inflammatory response. Several activating effects towards T cells, monocytes, endothelium cells and cytokine production have been reported suggesting a protective role of leptin in the setting of an acute systemic inflammation. However, the pathophysiological role of leptin during severe sepsis is currently not elucidated in detail. This study aims to investigate leptin expression in cultured human adipocytes within an inflammatory model and in patients suffering from severe sepsis and evaluates treatment effects of drotrecogin alpha (activated) (DAA), the recombinant form of human activated protein C. | ||
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