Nanoscopy in a living mouse brain
We demonstrated superresolution optical microscopy in a living higher animal. Stimulated emission depletion (STED) fluorescence nanoscopy reveals neurons in the cerebral cortex of a mouse with <70-nanometer resolution. Dendritic spines and their subtle changes can be observed at their relevant sc...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
3 February 2012
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| In: |
Science
Year: 2012, Volume: 335, Issue: 6068, Pages: 551-551 |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.1215369 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1126/science.1215369 Verlag, Volltext: http://science.sciencemag.org/content/335/6068/551 
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| Author Notes: | Sebastian Berning, Katrin I. Willig, Heinz Steffens, Payam Dibaj, Stefan W. Hell |
| Summary: | We demonstrated superresolution optical microscopy in a living higher animal. Stimulated emission depletion (STED) fluorescence nanoscopy reveals neurons in the cerebral cortex of a mouse with <70-nanometer resolution. Dendritic spines and their subtle changes can be observed at their relevant scales over extended periods of time. Super high-resolution microscopy resolves neuron dynamics in the cerebral cortex of a living mouse. Super high-resolution microscopy resolves neuron dynamics in the cerebral cortex of a living mouse. |
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| Item Description: | Gesehen am 31.10.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.1215369 |