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FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas

Lung cancer remains one of the most prominent public health challenges, accounting for the highest incidence and mortality among all human cancers. While pulmonary invasive mucinous adenocarcinoma (PIMA) is one of the most aggressive types of non-small cell lung cancer, transcriptional drivers of PI...

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Bibliographic Details
Main Authors: Milewski, David (Author) , Dienemann, Hendrik (Author) , Warth, Arne (Author) , Breuhahn, Kai (Author)
Format: Article (Journal)
Language:English
Published: December 21, 2017
In: PLoS Genetics
Year: 2017, Volume: 13, Issue: 12
ISSN:1553-7404
DOI:10.1371/journal.pgen.1007097
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pgen.1007097
Verlag, kostenfrei, Volltext: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007097
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Author Notes:David Milewski, David Balli, Vladimir Ustiyan, Tien Le, Hendrik Dienemann, Arne Warth, Kai Breuhahn, Jeffrey A. Whitsett, Vladimir V. Kalinichenko, Tanya V. Kalin

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520 |a Lung cancer remains one of the most prominent public health challenges, accounting for the highest incidence and mortality among all human cancers. While pulmonary invasive mucinous adenocarcinoma (PIMA) is one of the most aggressive types of non-small cell lung cancer, transcriptional drivers of PIMA remain poorly understood. In the present study, we found that Forkhead box M1 transcription factor (FOXM1) is highly expressed in human PIMAs and associated with increased extracellular mucin deposition and the loss of NKX2.1. To examine consequences of FOXM1 expression in tumor cells in vivo, we employed an inducible, transgenic mouse model to express an activated FOXM1 transcript in urethane-induced benign lung adenomas. FOXM1 accelerated tumor growth, induced progression from benign adenomas to invasive, metastatic adenocarcinomas, and induced SOX2, a marker of poorly differentiated tumor cells. Adenocarcinomas in FOXM1 transgenic mice expressed increased MUC5B and MUC5AC, and reduced NKX2.1, which are characteristics of mucinous adenocarcinomas. Expression of FOXM1 in KrasG12D transgenic mice increased the mucinous phenotype in KrasG12D-driven lung tumors. Anterior Gradient 2 (AGR2), an oncogene critical for intracellular processing and packaging of mucins, was increased in mouse and human PIMAs and was associated with FOXM1. FOXM1 directly bound to and transcriptionally activated human AGR2 gene promoter via the -257/-247 bp region. Finally, using orthotopic xenografts we demonstrated that inhibition of either FOXM1 or AGR2 in human PIMAs inhibited mucinous characteristics, and reduced tumor growth and invasion. Altogether, FOXM1 is necessary and sufficient to induce mucinous phenotypes in lung tumor cells in vivo. 
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